HOST IMMUNOLOGICAL MECHANISMS IN RESISTANCE OF MICE TO LEPTOSPIRAL INFECTIONS
HOST IMMUNOLOGICAL MECHANISMS IN RESISTANCE OF MICE TO LEPTOSPIRAL INFECTIONS
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DOI：
10.1128/iai.17.1.67-72.1977
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发表时间：
1977-01-01
影响因子：
3.1
通讯作者：
FAINE, S
中科院分区：
文献类型：
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作者：
ADLER, B;FAINE, S
对仓鼠和豚鼠具有毒性的几种钩端螺旋体血清型在用环磷酰胺免疫抑制的小鼠中引起急性致死性钩端螺旋体病。 BCG 疫苗和小棒状杆菌悬液均不影响免疫抑制或正常 BALB/c 小鼠的钩端螺旋体感染过程。裸无胸腺小鼠产生抗钩端螺旋体抗体，因此对钩端螺旋体感染具有抵抗力。裸鼠对环磷酰胺敏感，但如果它们从先前的感染或免疫中获得了抗体，则它们具有免疫力。显然，小鼠对原发感染的抵抗力和对再感染的免疫力完全是通过体液介导的。讨论了宿主和微生物因素在感染结果中的作用。
Several serovars of Leptospira virulent for hamsters and guinea pigs caused acute lethal leptospirosis in mice immunosuppressed with cyclophosphamide. Neither BCG vaccine nor Corynebacterium parvum suspension influenced the course of leptospiral infection in immunosuppressed or normal BALB/c mice. Nude athymic mice produced anti-leptospiral antibody and were therefore resistant to infection with leptospires. Nude mice were made susceptible with cyclophosphamide but were immune if they had acquired antibody from previous infection or immunization. Apparently mechanisms of resistance to primary infection and immunity to reinfection are exclusively humorally mediated in mice. The roles of host and microbial factors in the outcome of infection are discussed.