Oocyte Aging: The Role of Cellular and Environmental Factors and Impact on Female Fertility.
Oocyte Aging: The Role of Cellular and Environmental Factors and Impact on Female Fertility.
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DOI：
10.1007/5584_2019_456
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发表时间：
2020-01-01
影响因子：
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通讯作者：
El-Badri, Nagwa
中科院分区：
文献类型：
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作者：
Ahmed, Toka A;Ahmed, Sara M;El-Badri, Nagwa
女性衰老是影响人类生殖的重要因素之一。随着年龄的增长，女性生育能力自然下降。在30- 35岁的女性中，生育能力的下降是缓慢而稳定的;然而，由于卵巢储备和卵母细胞质量的下降，这种下降在35岁之后加速。人类卵母细胞老化受不同环境因素的影响，如饮食习惯和生活方式。卵巢微环境有助于卵母细胞老化和长寿。卵母细胞的直接微环境由周围的细胞组成。卵母细胞和微环境之间的串扰通过与周围细胞、细胞外基质和信号分子（包括激素、生长因子和代谢产物）的直接接触来介导。在这篇综述中，我们强调了不同的微环境因素，加速人类卵母细胞老化和降低卵母细胞功能。卵巢微环境以及环境污染物和不良饮食引起的压力，沿着其他因素，影响卵母细胞的质量和功能，并导致卵母细胞加速老化和不孕症疾病。
Female aging is one of the most important factors that impacts human reproduction. With aging, there is a natural decline in female fertility. The decrease in fertility is slow and steady in women aged 30-35years; however, this decline is accelerated after the age of 35 due to decreases in the ovarian reserve and oocyte quality. Human oocyte aging is affected by different environmental factors, such as dietary habits and lifestyle. The ovarian microenvironment contributes to oocyte aging and longevity. The immediate oocyte microenvironment consists of the surrounding cells. Crosstalk between the oocyte and microenvironment is mediated by direct contact with surrounding cells, the extracellular matrix, and signalling molecules, including hormones, growth factors, and metabolic products. In this review, we highlight the different microenvironmental factors that accelerate human oocyte aging and decrease oocyte function. The ovarian microenvironment and the stress that is induced by environmental pollutants and a poor diet, along with other factors, impact oocyte quality and function and contribute to accelerated oocyte aging and diseases of infertility.