Seasonal variation in Escherichia coli bloodstream infections in northern Israel
Seasonal variation in Escherichia coli bloodstream infections in northern Israel
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DOI：
10.1111/j.1469-0691.2010.03327.x
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发表时间：
2011-06-01
影响因子：
14.2
通讯作者：
Raz, R.
中科院分区：
文献类型：
--
作者：
Chazan, B.;Colodner, R.;Raz, R.
某些革兰氏阴性菌感染率的季节性变化先前已有描述，但关于大肠杆菌的研究很少。本研究的目的是调查大肠杆菌的发病率。大肠杆菌血流感染（BSI）和与温度在不同季节的伊兹拉埃尔山谷的关联。纳入了8年期间（2001年1月至2008年12月）送往Ha'Emek医疗中心微生物实验室的阳性血培养。将同期伊兹拉埃尔河谷的月平均气温与E. coli BSI率。我们将一年分为三个时期：冬季（12月至2月：平均温度< 15摄氏度），过渡期（3月，4月和11月：平均温度15-19摄氏度）和夏季（5月至10月：平均温度>= 20摄氏度）。此外，我们将同一时期内整个地区人群的平均每月抗生素使用量（以限定日总剂量衡量）与E。coli BSI。在研究期间，共记录了2810例BSI（35%为E。大肠杆菌）。67.4%的E.大肠杆菌菌血症，来源为泌尿系感染。E.大肠杆菌BSI为4.1/1000。培养物数量/月无差异（平均值：29 +/- 6）。然而，E.大肠杆菌BSI在夏季分别比过渡期和冬季高19%和21%（p0.01）。抗生素的消耗量在冬季明显较高。我们发现E.大肠杆菌BSI在夏季的表达。宿主、细菌和生态因素，以及冬季抗生素的高消耗，可以部分解释这些发现。
Seasonal variation in the infection rate with certain Gram-negative organisms has been previously described, but few studies have been published regarding Escherichia coli. The aim of this study was to investigate the incidence rate of E. coli bloodstream infection (BSI) and the association with temperature in different seasons in the Yizrael Valley. Positive blood cultures sent to the microbiology laboratory of Ha'Emek Medical Centre over a period of 8 years (January 2001 to December 2008) were included. The mean monthly temperature in the Yizrael Valley in the same period was compared with the monthly E. coli BSI rate. We divided the year into three periods: winter (December to February: mean temperature < 15 degrees C), transitional (March, April and November: mean temperature 15-19 degrees C) and summer (May to October: mean temperature >= 20 degrees C). In addition, we correlated the mean monthly antibiotic use in the same period measured as total defined daily doses for the whole regional population with E. coli BSI. During the study period, 2810 BSIs were recorded (35% E. coli). In 67.4% of the cases of E. coli bacteraemia, the source was urinary tract infection. The crude incidence of E. coli BSI was 4.1/1000 admissions. There was no difference in the number of cultures/month (mean: 29 +/- 6). However, E. coli BSI was 19% and 21% more frequent in summer than in the transitional and winter seasons, respectively (p 0.01). The antibiotic consumption was significantly higher in the winter period. We found significantly higher rates of E. coli BSI in the summer period. Host, bacterial and ecological factors, together with high consumption of antibiotics during the winter season, could partially explain these findings.