Identification and analysis of the myosin superfamily in Drosophila: a database approach.
Identification and analysis of the myosin superfamily in Drosophila: a database approach.
复制标题
果蝇肌球蛋白超家族的鉴定和分析：数据库方法。
DOI：
10.1023/a:1026589626422
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发表时间：
2000
影响因子：
2.7
通讯作者：
Anderson,JB
中科院分区：
文献类型：
--
作者：
Yamashita,RA;Sellers,JR;Anderson,JB
最近对黑腹果蝇基因组的测序为挖掘感兴趣的基因数据库提供了宝贵的资源。我们利用这个机会试图在果蝇中鉴定新的肌球蛋白，并确认先前鉴定的I、II、III、V、VI和VII类肌球蛋白的存在。果蝇数据库注释者预测了另外三种蛋白质的结构，我们将其鉴定为新的非常规肌球蛋白，其中两种分别属于XV和XVIII类。我们自己的努力预测了四个额外的部分序列的存在，这些序列似乎是肌凝蛋白，它们不属于任何特定的类别。在未来，比较基因组学有望将这些肌凝蛋白纳入新的类别。
The recent sequencing of the genome ofDrosophila melanogasterhas provided a valuable resource for mining the database for genes of interest. We took advantage of this opportunity in an attempt to identify novel myosins inDrosophilaand confirm the presence of the previously identified myosins from classes I, II, III, V, VI, and VII. TheDrosophiladatabase annotators predicted the structure of three additional proteins which we identified as novel unconventional myosins, two of which fell into classes XV and XVIII, respectively. Our own efforts predicted the presence of four additional partial sequences that appear to be myosin proteins which did not fall into any specific class. In the future comparative genomics will hopefully lead to the placement of these myosins into new classes.