Mycobacterium avium Subsp. paratuberculosis Induces Specific IgE Production in Japanese People with Allergies.
Mycobacterium avium Subsp. paratuberculosis Induces Specific IgE Production in Japanese People with Allergies.
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DOI：
10.1155/2017/7959154
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发表时间：
2017
影响因子：
2
通讯作者：
Momotani E
中科院分区：
文献类型：
--
作者：
Cossu D;Otsubo S;Otsubo Y;Eda S;Suzuki T;Iwao Y;Kuribayashi T;Yamamoto S;Sechi LA;Momotani E
背景。过敏症的患病率在全球范围内稳步上升；然而，发病机制仍不清楚。我们假设鸟分枝杆菌亚种。副结核病 (MAP) 可能会导致过敏的发生。这种生物体可以存在于乳制品中，它可以引发从 Th1 反应到 Th2 反应的免疫调节转换，并且推测它与多种人类自身免疫性疾病有关。为了确定其贡献，我们对 99 名患有各种特应性疾病的个体和 45 名健康非过敏对照者的血清进行了总 IgE 水平评估，并通过 ELISA 连续评估了 MAP 特异性 IgE。结果。过敏患者的平均血清总 IgE 水平为 256 ± 235 IU/mL，健康对照者为 62 ± 44 IU/mL（AUC = 0.88；p < 0.0001）。在患者组中，99 名受试者中有 50 名的 IgE 总水平升高≥ 150 IU/mL，而 49 名受试者的 IgE ≤ 150 IU/mL（平均水平：407 ± 256 IU/mL 对比 106 ± 16 IU/mL；p < 0.0001）。此外，50 名 IgE ≥ 150 IU/mL 受试者中有 6 名 (12%) 特定 MAP IgE 呈阳性，而 IgE ≤ 150 IU/mL 的受试者中无一人 (0%) 呈阳性（AUC = 0.63；p = 0.03）。结论。目前的研究表明，MAP 具有诱导特异性 IgE 的能力，可能有助于在遗传易感个体中诱导过敏性炎症。
Background. The prevalence of allergies is steadily increasing worldwide; however, the pathogenesis is still unclear. We hypothesized that Mycobacterium avium subsp. paratuberculosis (MAP) may contribute to allergy development. This organism can be present in dairy foods, it can elicit an immunomodulatory switch from a Th1 to a Th2 response, and it has been speculated that it is linked to several human autoimmune diseases. To determine the contribution, sera from 99 individuals with various atopic disorders and 45 healthy nonallergic controls were assessed for total IgE levels and successively for MAP-specific IgE by ELISA. Results. The mean total serum IgE level in allergic patients was 256 ± 235 IU/mL, and in the healthy controls it was 62 ± 44 IU/mL (AUC = 0.88; p < 0.0001). Among the patient groups, 50 of the 99 subjects had increased IgE total level ≥ 150 IU/mL, while 49 subjects had IgE ≤ 150 IU/mL (mean level: 407 ± 256 IU/mL versus 106 ± 16 IU/mL; p < 0.0001). Additionally, 6 out of 50 subjects (12%) with IgE ≥ 150 IU/mL and none (0%) with IgE ≤ 150 IU/mL were positive for specific MAP IgE (AUC = 0.63; p = 0.03). Conclusion. The present study revealed that MAP has the ability to induce specific IgE and might contribute to the induction of allergic inflammation in genetically predisposed individuals.