FEASIBILITY OF REIRRADIATION OF RECURRENT SINONASAL CARCINOMA IN THE PERIORBITAL REGION USING HYPOFRACTIONATED IMAGE-GUIDED INTENSITY-MODULATED RADIATION THERAPY
FEASIBILITY OF REIRRADIATION OF RECURRENT SINONASAL CARCINOMA IN THE PERIORBITAL REGION USING HYPOFRACTIONATED IMAGE-GUIDED INTENSITY-MODULATED RADIATION THERAPY
复制标题
DOI：
10.1002/hed.21385
复制
发表时间：
2011-09-01
影响因子：
2.9
通讯作者：
Lee, Nancy
中科院分区：
文献类型：
--
作者：
Thiagarajan, Anuradha;Mechalakos, James;Lee, Nancy
背景复发性眶周肿瘤给治疗带来了挑战，因为它们通常是不可切除的和化学难治性的。接近关键结构使得再照射困难。通过图像引导调强放射治疗（IG-IMRT），可以对患者设置进行实时校正，从而显著缩小计划靶体积边缘，并通过低分割实现安全剂量递增。在此，我们介绍了我们对一位眶周多次复发的鼻窦癌患者进行大分割IG-IMRT的经验。患者是一名67岁女性，患有鼻窦癌，接受了手术和2个高剂量放疗疗程。她在右侧眼眶出现了第二次肿瘤复发，并使用大分割IG-IMRT（24戈伊分3次）进行了再次照射。在4个月时观察到她的眼部症状几乎完全消退。进展扫描显示眼眶病变的大小减少。大分割IG-IMRT再照射的初步结果表明它是安全有效的。(C)2010 Wiley Periodicals，Inc.头颈部33：1372-1378，2011年
Background. Recurrent periorbital tumors pose management challenges because they are often unresectable and chemorefractory. Proximity to critical structures renders reirradiation difficult. With image-guided intensity-modulated radiation therapy (IG-IMRT), real-time corrections to patient setup are possible, enabling significant shrinkage of planning target volume margins and safe dose escalation with hypofractionation. Here, we present our experience with hypofractionated IG-IMRT in a patient with multiply recurrent sinonasal carcinomas in the periorbital region.Methods. The patient is a 67-year-old woman with sinonasal carcinoma, treated with surgery and 2 prior courses of high-dose radiotherapy. She developed a second tumor recurrence in the right lateral orbit, which was reirradiated using hypofractionated IG-IMRT (24 Gy in 3 fractions).Results. Near-complete resolution of her ocular symptoms was observed at 4 months. Progress scans demonstrated a decrease in size of the orbital lesion.Conclusion. Preliminary results of reirradiation using hypofractionated IG-IMRT suggest that it is safe and effective. (C) 2010 Wiley Periodicals, Inc. Head Neck 33: 1372-1378, 2011