Esterase-Sensitive and pH-Controlled Carbon Monoxide Prodrugs for Treating Systemic Inflammation
Esterase-Sensitive and pH-Controlled Carbon Monoxide Prodrugs for Treating Systemic Inflammation
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DOI：
10.1021/acs.jmedchem.9b00073
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发表时间：
2019-03-28
影响因子：
7.3
通讯作者：
Wang, Binghe
中科院分区：
文献类型：
--
作者：
Ji, Xingyue;Pan, Zhixiang;Wang, Binghe
开发基于CO的疗法的瓶颈是缺乏安全和可控的递送形式。在此，我们描述了努力与双响应内源性触发器的有机CO前药。一种代表性的CO前药在体外和LPS模拟的全身炎症模型中均显示出显著的抗炎作用。这些结果坚定地确立了这种CO前药作为用于治疗全身性炎症或炎症相关器官损伤的研究工具或候选化合物。
A bottleneck for developing CO-based therapeutics is the lack of a safe and controllable delivery form. Herein, we describe efforts toward organic CO prodrugs with dual-responsive endogenous triggers. One representative CO prodrug showed significant anti-inflammatory effects both in vitro and in a LPS-simulated systemic inflammation model. These results firmly establish such CO prodrugs as either research tools or candidate compounds for the treatment of systemic inflammation or inflammation related organ injuries.