Diet and cancer prevention: Contributions from the European Prospective Investigation into Cancer and Nutrition (EPIC) study
Diet and cancer prevention: Contributions from the European Prospective Investigation into Cancer and Nutrition (EPIC) study
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DOI：
10.1016/j.ejca.2010.07.025
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发表时间：
2010-09-01
影响因子：
8.4
通讯作者：
Riboli, Elio
中科院分区：
文献类型：
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作者：
Gonzalez, Carlos A.;Riboli, Elio
我们目前的主要研究结果观察到的日期从欧洲前瞻性调查癌症和营养（EPIC）的饮食因素与最常见的cancer sites.Methods：EPIC是一个多中心的前瞻性研究，在23个中心在10个欧洲国家：丹麦、法国、德国、希腊、意大利、荷兰、挪威、西班牙、瑞典和联合王国，包括519 978名参与者（366,521名女性和153,457名男性），大多数年龄在35-70岁。结果：我们观察到以下显着的关联：胃癌的风险与高血浆维生素C，一些类胡萝卜素，视黄醇和α-生育酚，高摄入量的谷物纤维和高粘附地中海饮食呈负相关，而红色和加工肉类与风险增加。膳食纤维、鱼类、钙和血浆维生素D的高摄入量与结直肠癌风险降低相关，而红肉和加工肉类摄入量、酒精摄入量、体重指数（BMI）和腹部肥胖与风险增加相关。目前吸烟者中水果和蔬菜的高摄入量与肺癌风险降低有关。患乳腺癌的风险增加与高饱和脂肪摄入和酒精摄入有关。在绝经后妇女中，BMI与乳腺癌风险呈正相关，体力活动与乳腺癌风险呈负相关。高乳制品蛋白质和钙的摄入量以及高血清IGF-I浓度与前列腺癌风险增加相关。这些结果有助于为旨在减少全球癌症负担的适当公共卫生战略和预防活动提供科学证据。(C)2010爱思唯尔有限公司版权所有。
We present the main findings observed to date from the European Prospective Investigation into Cancer and Nutrition (EPIC) on dietary factors associated with the most frequent cancer sites.Methods: EPIC is a multicentre prospective study carried out in 23 centres in 10 European countries: Denmark, France, Germany, Greece, Italy, the Netherlands, Norway, Spain, Sweden and the United Kingdom, including 519,978 participants (366,521 women and 153,457 men), most aged 35-70 years.Results: We observed the following significant associations: gastric cancer risk was inversely associated with high plasma vitamin C, some carotenoids, retinol and a-tocopherol, high intake of cereal fibre and high adhesion to Mediterranean diet, while red and processed meat were associated with increased risk. High intake of dietary fibre, fish, calcium, and plasma vitamin D were associated with a decreased risk of colorectal cancer, while red and processed meat intake, alcohol intake, body mass index (BMI) and abdominal obesity were associated with an increased risk. High intake of fruit and vegetables in current smokers were associated with a decreased risk of lung cancer. An increased risk of breast cancer was associated with high saturated fat intake and alcohol intake. In postmenopausal women, BMI was positively and physical activity negatively associated with breast cancer risk. High intake of dairy protein and calcium from dairy products and high serum concentration of IGF-I were associated with an increased risk of prostate cancer. These results contribute to scientific evidence for appropriate public health strategies and prevention activities aimed at reducing the global cancer burden. (C) 2010 Elsevier Ltd. All rights reserved.