Roles of Mucosal Immunity against Mycobacterium tuberculosis Infection.
Roles of Mucosal Immunity against Mycobacterium tuberculosis Infection.
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DOI：
10.1155/2012/791728
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发表时间：
2012
影响因子：
--
通讯作者：
Wang Y
中科院分区：
文献类型：
--
作者：
Li W;Deng G;Li M;Liu X;Wang Y
结核分枝杆菌（Mycobacterium tuberculosis，Mtb）是结核病（tuberculosis，TB）的病原体，是世界上发病率和死亡率最高的传染病之一。结核分枝杆菌作为一种粘膜传播的病原体，主要通过呼吸道粘膜组织感染人和动物。呼吸道粘膜除了提供抵抗病原体入侵的物理屏障外，其主要功能可能是作为诱导位点启动粘膜免疫应答，从而为宿主提供防御病原体的第一道防线。在动物和人类中的大量研究表明，粘膜免疫系统而不是全身免疫系统在宿主防御Mtb感染中起着重要作用。因此，开发能够直接诱导呼吸道粘膜免疫的新疫苗和新的递送途径被强调用于实现增强的对Mtb感染的保护。在本文中，我们概述了目前的知识状态，粘膜免疫对结核病感染，包括结核病疫苗的发展，呼吸道输送途径，以提高粘膜免疫进行了讨论。
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is one of the world's leading infectious causes of morbidity and mortality. As a mucosal-transmitted pathogen, Mtb infects humans and animals mainly through the mucosal tissue of the respiratory tract. Apart from providing a physical barrier against the invasion of pathogen, the major function of the respiratory mucosa may be to serve as the inductive sites to initiate mucosal immune responses and sequentially provide the first line of defense for the host to defend against this pathogen. A large body of studies in the animals and humans have demonstrated that the mucosal immune system, rather than the systemic immune system, plays fundamental roles in the host's defense against Mtb infection. Therefore, the development of new vaccines and novel delivery routes capable of directly inducing respiratory mucosal immunity is emphasized for achieving enhanced protection from Mtb infection. In this paper, we outline the current state of knowledge regarding the mucosal immunity against Mtb infection, including the development of TB vaccines, and respiratory delivery routes to enhance mucosal immunity are discussed.