Effect of cilostazol, a new antithrombotic drug, on cerebral circulation.
Effect of cilostazol, a new antithrombotic drug, on cerebral circulation.
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新型抗血栓药物西洛他唑对脑循环的影响。
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
Y. Kimura
中科院分区：
文献类型：
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作者：
K. Kawamura;K. Watanabe;Y. Kimura
本文研究了新型抗血栓药物西洛他唑（6-[4-（1-环己基-1H-四唑-5-基）丁氧基]-3，4-二氢-2（1H）-喹啉酮，OPC-13013）对脑血流量的影响及其扩血管作用的选择性。在麻醉犬中，西洛他唑以高于10 μ g/kg静脉注射剂量增加上级矢状窦的静脉流出。在麻醉猫中，通过氢清除法证明西洛他唑在高于10微克/kg/天的剂量下引起白色物质和灰质中的血流量的剂量依赖性增加。西洛他唑的有效剂量，当在ED 25值比较时，这是产生25%的血流量增加所需的剂量，几乎等于罂粟碱，并且比本环烷和喷替福林更有效。动脉血气分析显示静脉注射西洛他唑后pCO 2、pO 2和pH值无显著变化。在麻醉犬中，在恒定灌注压下动脉内给药后，西洛他唑以剂量依赖性方式增加颈总动脉、颈内动脉、椎动脉、上级肠系膜动脉和股动脉的血流量，剂量高于1 μ g，对肾血流量几乎没有影响。观察到对椎动脉和股动脉的高选择性。
The effects on cerebral blood flow and the selectivity of the vasodilating action of cilostazol (6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-qui nolinone, OPC-13013), a new antithrombotic drug, were investigated. In anesthetized dogs, cilostazol increased the venous outflow from the superior sagittal sinus in doses of higher than 10 micrograms/kg i.v. In anesthetized cats, cilostazol was demonstrated by the hydrogen clearance method to cause a dose-dependent increase in blood flow in both the white matter and the grey matter in doses of higher than 10 micrograms/kg/min i.v. The effective dose of cilostazol when compared at ED25 values, which is the dose required to produce a 25% increase in blood flow, was almost equal to that of papaverine and more potent than those of bencyclane and pentoxifylline. Arterial blood gas analysis revealed no significant changes in pCO2, pO2 and pH by intravenous administration of cilostazol. In anesthetized dogs, after intra-arterial administration at a constant perfusion pressure, cilostazol increased the blood flow of the common carotid, internal carotid, vertebral, superior mesenteric and femoral arteries in a dose-dependent manner in doses higher than 1 microgram, and had almost no effect on renal blood flow. High selectivity for the vertebral and femoral arteries was observed.