SCOTOPIC VISION DEFICITS IN YOUNG MONKEYS EXPOSED TO LEAD
SCOTOPIC VISION DEFICITS IN YOUNG MONKEYS EXPOSED TO LEAD
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DOI：
10.1126/science.403610
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发表时间：
1977-01-01
期刊：
影响因子：
56.9
通讯作者：
MARLAR, RJ
中科院分区：
文献类型：
--
作者：
BUSHNELL, PJ;BOWMAN, RE;MARLAR, RJ
恒河猴出生后第一年的血铅浓度分别为14微克/100毫升、55微克/100毫升或85微克/100毫升。18个月后，所有动物的血铅水平均正常。此时，相对于他们自己在强光下的表现以及其他组在所有使用的光水平下的表现，85µg组在暗光下的视觉辨别能力受到损害。这些结果可能反映了早期铅中毒造成的有害的、持久的暗视功能损害(夜盲)。
Rhesus monkeys were reared on diets designed to produce blood Pb concentrations of 14(untreated), 55 or 85 .mu.g/100 ml for the 1st yr of life. Eighteen months later, blood Pb levels were normal in all animals. At this time, visual discrimination performance in the 85 .mu.g group was impaired under dim light relative both to their own performance under bright light and to the performance of the other groups under all light levels used. These results may reflect a deleterious, enduring impairment of scotopic visual function (night blindness) as a result of early Pb intoxication.