Increasing prevalence of gestational diabetes mellitus (GDM) over time and by birth cohort - Kaiser permanente of Colorado GDM screening program
Increasing prevalence of gestational diabetes mellitus (GDM) over time and by birth cohort - Kaiser permanente of Colorado GDM screening program
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DOI：
10.2337/diacare.28.3.579
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发表时间：
2005-03-01
期刊：
影响因子：
16.2
通讯作者：
McDuffie, RS
中科院分区：
文献类型：
--
作者：
Dabelea, D;Snell-Bergeon, JK;McDuffie, RS
目的：妊娠期糖尿病（GDM）的患病率与2型糖尿病的患病率成正比。鉴于全球糖尿病患者的数量预计到2030年将以创纪录的水平增加，我们研究了不同种族GDM的时间趋势，研究设计和方法-凯撒永久的科罗拉多（KPCO）自1994年以来使用了标准的协议，普遍筛查GDM。本报告基于1994年至2002年发生的36，403例KPCO单胎妊娠，并研究了不同种族背景的妇女中GDM患病率的趋势。结果-KPCb成员中GDM的患病率从1994年至2002年翻了一番（2.1- 4.1%，P < 0.001），所有种族/种族组均显着增加。在逻辑回归分析中，诊断年份（每1年的比值比[OR]和95%CI = 1.12 [1.09 -1.14]）、母亲年龄（每5年的OR = 1.7 [1.6-1.8]）和非西班牙裔白色以外的种族（OR - 2.1 [1.9-2.4]）均与GDM显著相关。出生年份仍然显着（OR 1.06，P = 0.006），即使调整前GDM history.CONCLUSIONS -这项研究表明，GDM的患病率正在增加，在一个普遍筛选的多民族人口。GDM患病率的增加表明，最初在皮马印第安人中描述的妊娠糖尿病的恶性循环也可能发生在美国其他种族群体中。
OBJECTIVE - The prevalence of gestational diabetes mellitus (GDM) varies in direct proportion with the prevalence of type 2 diabetes in a given population or ethnic group. Given that the number of people with diabetes worldwide is expected to increase at record levels through 2030, we examined temporal trends in GDM among diverse ethnic groups.RESEARCH DESIGN AND METHODS - Kaiser Permanente of Colorado (KPCO) has used a standard protocol to universally screen for GDM since 1994. This report is based on 36,403 KPCO singleton pregnancies occurring between 1994 and 2002 and examines trends in GDM prevalence among women with diverse ethnic backgrounds.RESULTS - The prevalence of GDM among KPCb members doubled from 1994 to 2002 (2.1-4.1%, P < 0.001), with significant increases in all racial/ethnic groups. In logistic regression, year of diagnosis (odds ratio [OR] and 95% CI per 1 year = 1.12 [1,09-1.14]), mother's age (OR per 5 years = 1.7 [1.6-1.8]) and ethnicity other than non-Hispanic white (OR - 2.1 [1.9-2.4]) were all significantly associated with GDM. Birth year remained significant (OR 1.06, P = 0.006), even after adjusting for prior GDM history.CONCLUSIONS - This study shows that the prevalence of GDM is increasing in a universally screened multiethnic population. The increasing GDM prevalence suggests that the vicious cycle of diabetes in pregnancy initially described among Pima Indians may also be occurring among other U.S. ethnic groups.