INVOLVEMENT OF CENTRAL MU-OPIOID AND DELTA-OPIOID RECEPTORS IN MEDIATING THE REINFORCING EFFECTS OF BETA-ENDORPHIN IN THE RAT
INVOLVEMENT OF CENTRAL MU-OPIOID AND DELTA-OPIOID RECEPTORS IN MEDIATING THE REINFORCING EFFECTS OF BETA-ENDORPHIN IN THE RAT
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DOI：
10.1016/0014-2999(90)90153-w
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发表时间：
1990-01-03
影响因子：
5
通讯作者：
HERZ, A
中科院分区：
文献类型：
--
作者：
BALSKUBIK, R;SHIPPENBERG, TS;HERZ, A
使用无偏位置偏好条件化程序来鉴定中枢阿片样物质受体类型，通过所述中枢阿片样物质受体类型内源性阿片样物质肽β-阿片样物质肽β-阿片样物质受体β-内啡肽在大鼠体内发挥其强化作用。脑室内施用β-内啡肽和选择性μ。（DAGO）或δ。（DPDPE）阿片受体激动剂对药物相关部位产生明显的偏好。用选择性μ C预处理脑血管内。拮抗剂CTOP消除了DAGO产生的位置偏爱，但没有消除DPDPE产生的位置偏爱。用选择性δ预处理。拮抗剂ICI 174，864可消除DPDPE诱导的位置偏爱。它没有改变DAGO的效果。相反，用ICI 174，864或CTOP预处理消除了β-内啡肽这些数据表明，μ.和δ受体参与介导β-受体的增强效应。内啡肽，并表明这两种受体类型的激活是表达β-内啡肽的激励作用所必需的。内啡肽此外，他们建议，β-内啡肽通过与阿片样物质受体复合物的相互作用产生其激励作用，所述阿片样物质受体复合物由μ和δ受体。
An unbiased place preference conditioning procedure was used to identify the central opioid receptor types through which the endogenous opioid peptide, .beta.-endorphin, acts to exert its reinforcing effects in rats in vivo. The intracerebroventricular administration of .beta.-endorphin, and selective .mu. (DAGO) or .delta. (DPDPE) opioid receptor agonists produced marked preferences for the drug-associated place. Intracerebroventircular pretreatment with the selective .mu. antagonist, CTOP, elimated the place preference produced by DAGO but not that produced by DPDPE. Pretreatment with the selective .delta. antagonist, ICI 174,864, abolished the place preference induced by DPDPE. It did not modify the effect of DAGO. In contrast, pretreatment with either ICI 174,864 or CTOP abolished the effects of .beta.-endorphin. These data demonstrate that both .mu. and .delta. recptors are involved in mediating the reinforcing effect of .beta.-endorphin and indicate that the activation of both receptor types is required for the expression of the motivational effects of .beta.-endorphin. Further they suggest that .beta.-endorphin produces its motivational effects via an interaction with an opioid receptor complex composed of both .mu. and .delta. receptors.