Superparamagnetic iron oxide nanoparticles stabilized by alginate: Pharmacokinetics, tissue distribution, and applications in detecting liver cancers
Superparamagnetic iron oxide nanoparticles stabilized by alginate: Pharmacokinetics, tissue distribution, and applications in detecting liver cancers
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海藻酸盐稳定的超顺磁性氧化铁纳米颗粒：药代动力学、组织分布及其在肝癌检测中的应用
DOI：
10.1016/j.ijpharm.2007.11.036
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发表时间：
2008-04-16
影响因子：
5.8
通讯作者：
Nagai, Tsuneji
中科院分区：
文献类型：
--
作者：
Ma, Hui Li;Xu, Yu Feng;Nagai, Tsuneji
本研究的目的是描述海藻酸盐稳定的超顺磁性氧化铁纳米颗粒（SPIO-alginate）的药代动力学和组织分布，并探讨其作为一种新开发的磁共振造影剂在肝癌检测中的潜力。研究了spio -海藻酸盐在Sprague-Dawley大鼠体内的药动学和组织分布。结果表明，在109.5 μ mol Fe/kg条件下，spo -海藻酸盐迅速从血清中清除，半衰期为0.27 h，静脉注射后主要积聚在肝脏和脾脏中，总量占剂量的90%以上。SPIO-海藻酸盐在大鼠体内的药代动力学和分布研究表明，SPIO为基础的MR造影剂主要聚集在含有吞噬细胞的器官，即肝脏和脾脏。研究了spio -海藻酸盐注射前后对原发性肝癌大鼠和兔异种移植肝癌的检测效果。注射spio -海藻酸盐后，VX2肿瘤兔肝实质的信号强度明显降低，肝实质与肿瘤的对比明显。同时也证实了肝细胞癌在大鼠模型中的检测。本研究提供证据证明SPIO-海藻酸盐作为MR造影剂可能具有提高肝脏肿瘤的检测能力，其有效性与特异性定位于肝窦库普弗细胞的SPIO有关。(C) 2007 Elsevier B.V.版权所有
The objectives of this study were to describe the pharmacokinetics and tissue distribution of superparamagnetic iron oxide nanoparticle (SPIO) stabilized with alginate (SPIO-alginate), and investigate its potential in detecting liver cancers as a newly developed magnetic resonance (MR) contrast agent. Pharmacokinetics and tissue distribution of SPIO-alginate were investigated in Sprague-Dawley rats. The results showed that SPIO-alginate was eliminated rapidly from serum with the half-life of 0.27 h at 109.5 mu mol Fe/kg and accumulated dominantly in liver and spleen with a total percentage of more than 90% of dose after intravenous injection. The studies of pharmacokinetics and distribution of SPIO-alginate in rats indicated the MR contrast agent, based on SPIO, mainly accumulating in targeting organs that contain phagocytosing cells, i.e. liver and spleen. The efficacies in detecting hepatocellular carcinoma (HCC) of rat with primary liver cancer and xenograft liver cancers of rabbit were investigated before and after injection of SPIO-alginate. The signal intensity of Ever parenchyma in rabbit with VX2 tumor after injection of SPIO-alginate was reduced sharply resulting in a significant contrast between liver parenchyma and tumor. Detection of the HCC in rat model was also demonstrated. The present study provides evidence that SPIO-alginate might have the ability to improve the detection of liver tumors as an MR contrast agent, and the efficacy is associated with the SPIO specifically located in Kupffer cells in hepatic sinusoid. (C) 2007 Elsevier B.V. All rights reserved.