Effects of acute and repeated restraint stress on gaba efflux in the rat basolateral and central amygdala
Effects of acute and repeated restraint stress on gaba efflux in the rat basolateral and central amygdala
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DOI：
10.1016/j.brainres.2008.12.022
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发表时间：
2009-02-23
期刊：
影响因子：
2.9
通讯作者：
Fadel, Jim R.
中科院分区：
文献类型：
--
作者：
Reznikov, Leah R.;Reagan, Lawrence P.;Fadel, Jim R.
压力可以促使多种情绪相关疾病的发作，包括抑郁症。对这种现象的神经基础的研究强调了杏仁核是一个关键组成部分。杏仁核活性和结构的改变伴随着各种情绪相关的障碍，有趣的是，反复应激的动物杏仁核形态和行为也会发生改变。γ-氨基丁酸（GABA）在杏仁核中的传输是一个重要的手段，通过它可以控制信息流，活动和功能，因此，我们确定了急性和重复约束应激（RRS）对GABA流出的基底外侧和中央杏仁复合体的影响。体内微透析显示，急性束缚应激增加了基底外侧杏仁核中GABA的流出，而中央杏仁核的流出保持不变。先前反复应激的动物没有表现出急性应激介导的GABA流出增加基底外侧杏仁核，伴随着基础GABA浓度没有变化的事件。相反，重复束缚应激对CeA中GABA的流出或基础GABA水平没有影响。总的来说，这些数据表明，急性应激elephants独特的和区域特异性的增加，在大鼠杏仁核的GABA流出，和以前的重复压力差异修改这种反应。(C)2008 Elsevier B. V.保留所有权利。
Stress can precipitate onset of multiple mood-related disorders, including depression. Examination of the neural basis of this phenomenon has highlighted the amygdala as a key component. Alterations in amygdalar activity and structure accompany various mood-related disorders, and interestingly, amygdalar morphology and behavior can be altered in animals subjected to repeated stress. Gamma-aminobutyric acid (GABA) transmission in the amygdala represents an important means by which information flow, activity, and function can be controlled; therefore, we determined the effects of acute and repeated restraint stress (RRS) on GABA efflux in the basolateral and central amygdalar complexes. In vivo microdialysis revealed that acute restraint stress increased GABA efflux in the basolateral amygdala, whereas central amygdala efflux remained unchanged. Animals subjected to prior repeated stress displayed no acute stress-mediated increases in GABA efflux in the basolateral amygdala, an event accompanied by no changes in basal GABA concentrations. Conversely, repeated restraint stress had no effect on GABA efflux or basal GABA levels in the CeA. Collectively, these data demonstrate that acute stress elicits unique and region-specific increases in GABA efflux in the rat amygdala, and that prior repeated stress differentially modifies this response. (C) 2008 Elsevier B.V. All rights reserved.