Regulatory role of JMJD6 in placental development
Regulatory role of JMJD6 in placental development
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DOI：
10.1017/erm.2022.30
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Guoning Huang
中科院分区：
文献类型：
--
作者：
Xiaoli Shen;Christian De Geyter;Hong Zhang;Guoning Huang
Correct placental development and function are critical to both the mother’s and the foetus’.health during pregnancy. Placental function depends on the correct development of the.vascular network, which requires proper angiogenesis. Impaired angiogenesis in the placenta.can induce foetal growth restriction, preeclampsia, and even foetal death. Placental angiogenesis.is finely controlled by ubiquitous and pregnancy-specific angiogenic factors. Jumonji.domain-containing protein 6 (JMJD6) is a Fe (II)- and 2-oxoglutarate (2OG)-dependent.oxygenase that catalyses arginine demethylation and lysine hydroxylation of histone and.non-histone peptides. JMJD6 has been implicated in embryonic development, cellular proliferation.and migration, self-tolerance induction in the thymus, and adipocyte differentiation..In this review we present JMJD6’s structure and activity, as well as its role in angiogenesis,.oxygen sensing, and adverse pregnancy outcomes related to placental development..Understanding the interaction between JMJD6 and other placental factors may identify potential.therapeutic targets for correcting abnormal placental angiogenesis and function.
