Association between multi-level inorganic arsenic exposure from drinking water and skin lesions in China.
Association between multi-level inorganic arsenic exposure from drinking water and skin lesions in China.
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DOI：
10.3390/ijerph2006030031
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发表时间：
2006-09
影响因子：
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通讯作者：
Japan Inner Mongolia Arsenic Pollution Study Group
中科院分区：
文献类型：
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作者：
Guo X;Fujino Y;Ye X;Liu J;Yoshimura T;Japan Inner Mongolia Arsenic Pollution Study Group
砷是环境中最重要的有毒物质之一。在中国内蒙古，据信有30万居民正在饮用每升含有50微克的水。众所周知，皮肤损伤是长期接触砷最常见的后果。为了明确砷致皮肤病变的患病率，评估这一问题在目标人群中的影响，并制定未来的规划是很重要的。我们评估了中国内蒙古砷污染地区饮用水中多层次无机砷暴露与皮肤病变之间的关系。在砷高（50μg/l）村和低（<50μg/l）村分别招募了199名和32名受试者，并对其进行了详细的体格检查，特别强调砷相关的皮肤病变。对每个参与者的砷暴露量进行了测量，包括原始井的砷浓度和使用井的持续时间。两个村庄分别有56名和3名受试者被诊断为砷诱发的皮肤病变，包括角化病、色素沉着和/或色素沉着。通过逻辑回归计算与砷暴露相关的皮肤病变的奇比，并对性别、年龄组、吸烟情况和暴露时间进行调整。砷暴露水平与皮肤损伤风险之间存在一致的剂量-反应关系。与iAs浓度<50μg/l组相比，iAs浓度51 ~ 99、100 ~ 149和>组的皮肤病变校正比值比分别为33.3% （OR= 15.50, 95% CI: 1.53 ~ 248.70）、46.7% （OR= 16.10, 95% CI: 3.73 ~ 69.63）和55.7% （OR= 25.70, 95% CI: 6.43 ~ 102.87）。在这一人群中，使用良好的持续时间与皮肤病变风险增加无关；（OR =1.68, 95% CI: 0.40-6.91, OR = 2.30, 95% CI: 0.58-9.14，超过15年）与持续时间少于5年的患者相比。
Arsenic is one of the most important toxicants in the environment. In Inner Mongolia of China, 300,000 residents are believed to be drinking water containing >50μg/liter. Skin lesions have been known as the most common consequences resulting from chronic exposure to arsenic. To clarify the prevalence of arsenic-induced skin lesions, it is important to assess the impact of this problem among the target population, and to make future planning. We evaluated the association between multi-levels inorganic arsenic exposure from drinking water and skin lesions in an arsenic-affected area in Inner Mongolia, China. One hundred nine and 32 subjects in high (>50μg/liter) and low (<50μg/liter) arsenic-affected villages were recruited and had the detailed physical examination with special emphasis on arsenic-related skin lesions. Arsenic exposure was measured for each participant with respect to iAs concentration of primary well and the duration using the well. Arsenic-induced skin lesions including keratosis, pigmentation, and/or depigmentation were diagnosed in 56 and 3 subjects in the two villages, respectively. Logistic regression was conducted to calculate odd ratios of skin lesions associated with arsenic exposure with adjustments for sex, age group, smoking and duration of exposure. A consistent dose-response relationship between arsenic exposure level and skin lesion risk was observed. Compared to those with iAs concentration <50μg/liter, the adjusted odds ratios of skin lesions for the subjects with 51–99, 100–149 and >150μg/liter were 33.3% (OR =15.50, 95% CI: 1.53–248.70), 46.7% (OR =16.10, 95% CI: 3.73–69.63) and 55.7% (OR= 25.70, 95% CI: 6.43–102.87), respectively. Duration of using well was not associated with increased risk of skin lesions in this population; (OR =1.68, 95% CI: 0.40–6.91 for 6–15 years, OR = 2.30, 95% CI: 0.58–9.14 for over 15 years) compared with the duration of less than 5 years.