Is mitochondrial antibody diagnostic of primary biliary cirrhosis?
Is mitochondrial antibody diagnostic of primary biliary cirrhosis?
复制标题
线粒体抗体可以诊断原发性胆汁性肝硬化吗？
作者：
L. Muñoz;H. Thomas;P. Scheuer;D. Doniach;S. Sherlock
在218例诊断为原发性胆汁性肝硬化的患者中，只有9例血清线粒体抗体呈阴性。在检查来自这些患者的其他标本时，发现7例呈阳性，最终发病率大于99%。两例血清线粒体抗体呈阴性的患者，其肝脏组织学符合原发性胆汁性肝硬化的诊断，但无法得到确切的诊断。另外三名无症状且血清碱性磷酸酶正常的线粒体抗体阳性受试者在肝活检中显示为I期原发性胆汁性肝硬化。有或无肝功能检查异常的患者血清线粒体抗体阳性强烈提示原发性胆汁性肝硬化的诊断。
In a series of 218 patients diagnosed as having primary biliary cirrhosis only nine exhibited a negative serum mitochondrial antibody. On examining additional specimens from these patients, seven were found to be positive, giving a final incidence of greater than 99%. The two patients whose sera remained negative for the mitochondrial antibody had liver histology compatible with the diagnosis of primary biliary cirrhosis, but a firm diagnosis could not be reached. Three additional mitochondrial antibody positive subjects who were asymptomatic and exhibited normal serum alkaline phosphatase were shown on liver biopsy to have stage I primary biliary cirrhosis. The presence of a positive serum mitochondrial antibody in a patient with or without abnormalities in liver function tests strongly suggests the diagnosis of primary biliary cirrhosis.