Immune activation modulates hematopoiesis through interactions between CD27 and CD70
Immune activation modulates hematopoiesis through interactions between CD27 and CD70
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DOI：
10.1038/ni1174
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发表时间：
2005-04-01
影响因子：
30.5
通讯作者：
van Oers, MHJ
中科院分区：
文献类型：
--
作者：
Nolte, MA;Arens, R;van Oers, MHJ
造血干细胞向成熟血细胞谱系的分化受到严格调控。在这里，我们报告说，CD27，这是表达在干细胞和早期祖细胞在骨髓中，可以在这个过程中很重要。在竞争性移植实验中，CD 27的缺失增加了干细胞和早期祖细胞的髓样集落形成潜力，并增强了B淋巴重建能力。相反，用CD27的独特配体CD70刺激CD27（+）祖细胞，在体外抑制集落形成潜力，在体内抑制淋巴细胞生长。由于CD70仅在活化的免疫细胞上表达，我们认为CD27对早期祖细胞的触发在免疫活化期间为白细胞分化提供了负反馈信号。
The differentiation of hematopoietic stem cells into mature blood cell lineages is tightly regulated. Here we report that CD27, which is expressed on stem and early progenitor cells in bone marrow, can be important in this process. Deletion of CD27 increased the myeloid colony - forming potential of stem and early progenitor cells and enhanced B lymphoid reconstitutive capacity in competitive transplantation experiments. Conversely, stimulation of CD27(+) progenitor cells with CD70, the unique ligand for CD27, inhibited colony-forming potential in vitro and lymphocyte outgrowth in vivo. As CD70 is expressed only on activated immune cells, we suggest that CD27 triggering on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation.