Reciprocal patterns of c-Fos expression in the medial prefrontal cortex and amygdala after extinction and renewal of conditioned fear
Reciprocal patterns of c-Fos expression in the medial prefrontal cortex and amygdala after extinction and renewal of conditioned fear
复制标题
DOI：
10.1101/lm.1463909
复制
发表时间：
2009-08-01
影响因子：
2
通讯作者：
Maren, Stephen
中科院分区：
文献类型：
--
作者：
Knapska, Ewelina;Maren, Stephen
在条件性恐惧消退之后，对条件性恐惧和消退体验的记忆变得依赖于环境。恐惧在灭绝情境中被抑制，但在其他情境中又会重新出现。本研究的特点是神经回路的背景依赖性检索熄灭的恐惧记忆使用c-Fos免疫组化。在恐惧条件化和消退到听觉条件刺激（CS）后，大鼠在消退背景或第二背景中呈现熄灭的CS，然后处死。在灭绝背景下出现CS会产生低水平的条件性冻结，并诱导内侧前额叶皮质边缘下区、杏仁核闰核和齿状回（DG）中的c-Fos表达。相比之下，介绍CS外的灭绝上下文产生了高水平的条件冻结和诱导c-Fos的表达，在前边缘核分裂的内侧前额叶皮层，杏仁核的外侧和基底外侧核，杏仁核的中央核的内侧分裂。海马CA 1和CA 3区表现出c-Fos表达时，CS在任何情况下。这些数据表明，背景特异性的灭绝是介导的杏仁核活动的前额叶调制，海马在上下文记忆检索的基础作用。
After extinction of conditioned fear, memory for the conditioning and extinction experiences becomes context dependent. Fear is suppressed in the extinction context, but renews in other contexts. This study characterizes the neural circuitry underlying the context-dependent retrieval of extinguished fear memories using c-Fos immunohistochemistry. After fear conditioning and extinction to an auditory conditioned stimulus (CS), rats were presented with the extinguished CS in either the extinction context or a second context, and then sacrificed. Presentation of the CS in the extinction context yielded low levels of conditioned freezing and induced c-Fos expression in the infralimbic division of the medial prefrontal cortex, the intercalated nuclei of the amygdala, and the dentate gyrus (DG). In contrast, presentation of the CS outside of the extinction context yielded high levels of conditioned freezing and induced c-Fos expression in the prelimbic division of the medial prefrontal cortex, the lateral and basolateral nuclei of the amygdala, and the medial division of the central nucleus of the amygdala. Hippocampal areas CA1 and CA3 exhibited c-Fos expression when the CS was presented in either context. These data suggest that the context specificity of extinction is mediated by prefrontal modulation of amygdala activity, and that the hippocampus has a fundamental role in contextual memory retrieval.