Association of mammographic density with hormone receptors in invasive breast cancers: Results from a case-only study
Association of mammographic density with hormone receptors in invasive breast cancers: Results from a case-only study
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DOI：
10.1002/ijc.27515
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发表时间：
2012-12-01
影响因子：
6.4
通讯作者：
Fasching, Peter A.
中科院分区：
文献类型：
--
作者：
Heusinger, Katharina;Jud, Sebastian M.;Fasching, Peter A.
对于许多乳腺癌（BC）的风险因素，有越来越多的证据表明，分子亚型的风险因素是特定的。关于乳腺摄影密度（MD），关于其与雌激素受体（ER）和孕激素受体（PR）表达的相关性的数据不一致。本研究的目的是分析ER和PR表达与MD的关系。在我们的仅病例研究中，2,410例发生BC的患者的BC风险因素、激素受体表达和MD数据可用。每名患者由两名阅片员使用半自动化方法评估MD（PMD）百分比。ER/PR与PMD的相关性通过多因素协方差分析进行研究，PMD作为目标变量，包括与MD相关的众所周知的因素，如年龄，产次，激素替代疗法的使用和体重指数（BMI）。除了众所周知的PMD与年龄、产次、BMI和激素替代治疗之间的关联外，还发现PMD与ER表达水平之间存在显著的负相关。ER阴性肿瘤患者的平均PMD为38%，而ER高表达患者的PMD为35%。PMD和PR表达之间的正相关的统计趋势也被看到。PMD似乎与ER表达呈负相关，可能与PR表达呈正相关。这些影响独立于其他风险因素，如年龄，BMI，产次和激素替代治疗，可能表明介导这种影响的其他途径。
For many breast cancer (BC) risk factors, there is growing evidence concerning molecular subtypes for which the risk factor is specific. With regard to mammographic density (MD), there are inconsistent data concerning its association with estrogen receptor (ER) and progesterone receptor (PR) expression. The aim of our study was to analyze the association between ER and PR expression and MD. In our case-only study, data on BC risk factors, hormone receptor expression and MD were available for 2,410 patients with incident BC. MD was assessed as percent MD (PMD) using a semiautomated method by two readers for every patient. The association of ER/PR and PMD was studied with multifactorial analyses of covariance with PMD as the target variable and including well-known factors that are also associated with MD, such as age, parity, use of hormone replacement therapy, and body mass index (BMI). In addition to the commonly known associations between PMD and age, parity, BMI and hormone replacement therapy, a significant inverse association was found between PMD and ER expression levels. Patients with ER-negative tumors had an average PMD of 38%, whereas patients with high ER expression had a PMD of 35%. A statistical trend toward a positive association between PMD and PR expression was also seen. PMD appears to be inversely associated with ER expression and may correlate positively with PR expression. These effects were independent of other risk factors such as age, BMI, parity, and hormone replacement therapy, possibly suggesting other pathways that mediate this effect.