The international collaborative on fatigue following infection (COFFI)
The international collaborative on fatigue following infection (COFFI)
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DOI：
10.1080/21641846.2018.1426086
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发表时间：
2018-01-01
影响因子：
2.8
通讯作者：
Lloyd, Andrew
中科院分区：
文献类型：
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作者：
Katz, Ben Z.;Collin, Simon M.;Lloyd, Andrew
背景：感染后疲劳合作(COFI)的目的是为了让感染后疲劳(PIE)和其他综合征的研究人员通过研究具有已知感染诱因的相对同种人群来合作解决这些神秘且鲜为人知的疾病。利用COFI、汇集数据和储存的生物样本将为流行病学和实验室研究提供支持，以更好地了解PIF发生和进展的病因和危险因素。方法：COFI由来自英国、荷兰、挪威、美国、新西兰和澳大利亚的前瞻性队列组成，一些队列关闭，一些队列开放招募。接近招募的9个队列总共有3000多名参与者，包括近1000名传染性单核细胞增多症(IM)患者、500名Q热患者、800名贾第鞭毛虫病患者、600名弯曲杆菌胃肠炎患者、190名退伍军人症患者和60名罗斯河病毒患者。随访时间至少为6个月，最长为10年。所有研究都采用福田标准来定义慢性疲劳综合征。结果：初步分析表明，慢性疲劳综合征不能恢复的危险因素包括身体素质较低、女性、急性疾病反应的严重程度和自主神经功能障碍。结论：COFI(https://internationalcoffi.wordpress.com/))是一个国际合作组织，应该能够回答基于汇集数据的问题，而这些问题在个人队列中无法回答。可能的问题可能包括：不同的感染是否会引发不同的PIF综合征(例如CFS和肠易激综合征)？PIF的纵向预测因子及其严重程度是什么？
Background: The purpose of the Collaborative on Fatigue Following Infection (COFFI) is for investigators of post-infection fatigue (PIE) and other syndromes to collaborate on these enigmatic and poorly understood conditions by studying relatively homogeneous populations with known infectious triggers. Utilising COFFI, pooled data and stored biosamples will support both epidemiological and laboratory research to better understand the etiology and risk factors for development and progression of PIF.Methods: COFFI consists of prospective cohorts from the UK, Netherlands, Norway, USA, New Zealand and Australia, with some cohorts closed and some open to recruitment. The 9 cohorts closed to recruitment total over 3000 participants, including nearly 1000 with infectious mononucleosis (IM), > 500 with Q fever, > 800 with giardiasis, > 600 with campylobacter gastroenteritis (CG), 190 with Legionnaires disease and 60 with Ross River virus. Follow-ups have been at least 6 months and up to 10 years. All studies use the Fukuda criteria for defining chronic fatigue syndrome (CFS).Results: Preliminary analyses indicated that risk factors for nonrecovery from PIF included lower physical fitness, female gender, severity of the acute sickness response, and autonomic dysfunction.Conclusions: COFFI (https://internationalcoffi.wordpress.com/) is an international collaboration which should be able to answer questions based on pooled data that are not answerable in the individual cohorts. Possible questions may include the following: Do different infections trigger different PIF syndromes (e.g. CFS vs. irritable bowel syndrome)?; What are longitudinal predictors of PIF and its severity?