[THE CHARACTERISTICS OF RETINA AT THE DEVELOPMENT OF PROLIFERATIVE VITREORETINOPATHY IN RATS AFTER INTRAOCULAR INJECTION OF CONCANAVALIN A AND DISPASE].
[THE CHARACTERISTICS OF RETINA AT THE DEVELOPMENT OF PROLIFERATIVE VITREORETINOPATHY IN RATS AFTER INTRAOCULAR INJECTION OF CONCANAVALIN A AND DISPASE].
复制标题
眼内注射刀豆蛋白A及分散后大鼠增殖性玻璃体视网膜病变发展过程中视网膜的特征
DOI：
--
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
S. Gavrilova
中科院分区：
文献类型：
--
作者：
A. Erdiakov;M. Tikhonovich;E. Rzhavina;S. Gavrilova
本文综述了两种大鼠增生性玻璃体视网膜病变模型的优点：玻璃体内注射蛋白水解酶分散酶和促炎凝集素伴刀豆球蛋白A。我们第一次选择了明确的形态学标准，在炎症反应的视网膜评价。并比较了给药后第7天注射分散酶和刀豆球蛋白的效果。结论：不同剂量的分散酶可在注射后不同时期获得稳定的PVR模型。
In this article we review and discuss the advantages of two proliferative vitreoretinopathy models in rats: intravitreal injection of proteolytic enzyme dispase and proinflammatory lectin concanavalin A. For the first time we selected clear morphological criteria for the retina evaluation during the inflammatory response. We also compared the effects of the injection of dispase and concanavalin on the 7th day after the drugs administration. We conclude that different doses of dispase can be used to get a stable model of PVR on different periods after the injection procedure.