Modulation of autoimmunity with artificial peptides.
Modulation of autoimmunity with artificial peptides.
复制标题
用人工肽调节自身免疫。
DOI：
10.1016/j.autrev.2010.08.017
复制
发表时间：
2010
影响因子：
13.6
通讯作者：
LaCava,Antonio
中科院分区：
文献类型：
--
作者：
LaCava,Antonio
对自身抗原免疫耐受性的丧失导致自身免疫反应的发展。由于自身抗原通常是多重的和/或它们的序列可能是未知的，一种恢复免疫耐受的方法是使用人工合成的肽来干扰或竞争驱动自身免疫过程的细胞相互作用网络中的自身肽。本文综述了在自身免疫中使用人工肽的基本原理及其作用机制。提供了在临床前研究和人类自身免疫性疾病管理中使用人工肽的实例。
The loss of immune tolerance to self antigens leads to the development of autoimmune responses. Since self antigens are often multiple and/or their sequences may not be known, one approach to restore immune tolerance uses synthetic artificial peptides that interfere or compete with self peptides in the networks of cellular interactions that drive the autoimmune process. This review describes the rationale behind the use of artificial peptides in autoimmunity and their mechanisms of action. Examples of use of artificial peptides in preclinical studies and in the management of human autoimmune diseases are provided.