Inverted U-shaped correlation between serum low-density lipoprotein cholesterol levels and cognitive functions of patients with type 2 diabetes mellitus.
Inverted U-shaped correlation between serum low-density lipoprotein cholesterol levels and cognitive functions of patients with type 2 diabetes mellitus.
复制标题
2型糖尿病患者血清低密度脂蛋白胆固醇水平与认知功能的倒U型相关
DOI：
10.1186/s12944-021-01534-5
复制
发表时间：
2021-09-12
影响因子：
4.5
通讯作者：
Wang S
中科院分区：
文献类型：
--
作者：
Zhang H;Zhu W;Niu T;Wang Z;An K;Cao W;Shi J;Wang S
BackgroundLow-density lipoprotein cholesterol (LDL-C) metabolic disorder is common in individuals with diabetes. The role of LDL-C in mild cognitive impairment (MCI) remains to be explored. We aim to investigate the associations between LDL-C at different levels and details of cognition decline in patients with type 2 diabetes mellitus (T2DM).MethodsPatients with T2DM (n= 497) were recruited. Clinical parameters and neuropsychological tests were compared between patients with MCI and controls. Goodness of fit was assessed to determine the linear or U-shaped relationship between LDL-C and cognitive function. The cut-off point of LDL-C was calculated. Correlation and regression were carried out to explore the relationship between cognitive dysfunction and LDL-C levels above and below the cut-off point.ResultsAlthough no significant difference in LDL-C levels was detected in 235 patients with MCI, compared with 262 patients without MCI, inverted-U-shaped association was determined between LDL-C and Montreal Cognitive Assessment (MoCA). The cut-off point of LDL-C is 2.686 mmol/l. LDL-C (>2.686 mmol/l) is positively related to Trail Making Test B (TMTB) indicating executive function. LDL-C (<2.686 mmol/l) is positively associated with Clock Drawing Test (CDT) reflecting visual space function in patients with T2DM.ConclusionInverted U-shaped correlation was found between serum LDL-C and cognitive function in patients with T2DM. Despite that the mechanisms of different LDL-C levels involved in special cognitive dysfunctions remain incompletely clarified, excessive LDL-C damages executive function, while the deficient LDL-C impairs visual space function.Trial registrationChiCTR-OCC-15006060 .
登录
查看更多内容
ABCA1 R219K 多态性和血清脂质谱对 2 型糖尿病轻度认知障碍的影响
影响因子：
4.8
作者：
Cai R;Han J;Sun J;Huang R;Tian S;Shen Y;Wang S
通讯作者：
Wang S
影响因子：
4.8
作者：
Fukui, Kenji;Ferris, Heather A.;Kahn, C. Ronald
通讯作者：
Kahn, C. Ronald
影响因子：
5
作者：
Genaro-Mattos, Thiago C.;Anderson, Allison;Mirnics, Karoly
通讯作者：
Mirnics, Karoly
影响因子：
7
作者：
Leung, Jess L. M.;Lee, Gary T. H.;Wu, Jimmy Y. M.
通讯作者：
Wu, Jimmy Y. M.
来自小鼠大脑多个区域的老化星形胶质细胞转录组。
影响因子：
8.8
作者：
Boisvert MM;Erikson GA;Shokhirev MN;Allen NJ
通讯作者：
Allen NJ