Abnormal Grey Matter Arteriolar Cerebral Blood Volume in Schizophrenia Measured With 3D Inflow-Based Vascular-Space-Occupancy MRI at 7T
Abnormal Grey Matter Arteriolar Cerebral Blood Volume in Schizophrenia Measured With 3D Inflow-Based Vascular-Space-Occupancy MRI at 7T
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DOI：
10.1093/schbul/sbw109
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发表时间：
2017-05-01
影响因子：
6.6
通讯作者：
Margolis, Russell L.
中科院分区：
文献类型：
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作者：
Hua, Jun;Brandt, Allison S.;Margolis, Russell L.
代谢障碍和微血管异常可能与精神分裂症的发病有关。以往关于精神分裂症脑灌注的研究大多是测量脑内总脑血容量（CBV）和脑血流量（CBF），它们反映了来自微血管的小动脉、毛细血管和静脉室的集合信号。由于小动脉是这些隔室中调节最活跃的血管，它们可能是微血管系统中对代谢紊乱最敏感的成分。在本研究中，我们采用基于血流的血管空间占用（iVASO） MRI方法研究精神分裂症患者大脑小动脉（piial）和小动脉血管（arteriolar cerebral blood volume [CBVa]）体积的变化。将iVASO方法扩展到三维（3D）全脑覆盖，并在超高磁场（7T）下测量12名精神分裂症患者和12名匹配对照的脑CBVa。患者全脑多个区域的灰质（GM） CBVa显著减少（相对变化为14%-51%，效应值为0.7-2.3）。颞叶皮层多个区域的GM CBVa值与患者疾病持续时间呈显著负相关。在一些大脑区域也发现了转基因CBVa的增加。我们的研究结果表明，微血管异常可能在精神分裂症中发挥作用，并提示转基因CBVa可能是该疾病的潜在标志物。需要进一步的研究来阐明这种影响是由于原发性血管损伤还是继发于其他原因，如代谢功能障碍。
Metabolic dysfunction and microvascular abnormality may contribute to the pathogenesis of schizophrenia. Most previous studies of cerebral perfusion in schizophrenia measured total cerebral blood volume (CBV) and cerebral blood flow (CBF) in the brain, which reflect the ensemble signal from the arteriolar, capillary, and venular compartments of the microvasculature. As the arterioles are the most actively regulated blood vessels among these compartments, they may be the most sensitive component of the microvasculature to metabolic disturbances. In this study, we adopted the inflow-based vascular-space-occupancy (iVASO) MRI approach to investigate alterations in the volume of small arterial (pial) and arteriolar vessels (arteriolar cerebral blood volume [CBVa]) in the brain of schizophrenia patients. The iVASO approach was extended to 3-dimensional (3D) whole brain coverage, and CBVa was measured in the brains of 12 schizophrenia patients and 12 matched controls at ultra-high magnetic field (7T). Significant reduction in grey matter (GM) CBVa was found in multiple areas across the whole brain in patients (relative changes of 14%-51% and effect sizes of 0.7-2.3). GM CBVa values in several regions in the temporal cortex showed significant negative correlations with disease duration in patients. GM CBVa increase was also found in a few brain regions. Our results imply that microvascular abnormality may play a role in schizophrenia, and suggest GM CBVa as a potential marker for the disease. Further investigation is needed to elucidate whether such effects are due to primary vascular impairment or secondary to other causes, such as metabolic dysfunction.