Self- and Informant-Reported Memory Complaints: Frequency and Severity in Cognitively Intact Individuals and those with Mild Cognitive Impairment and Neurodegenerative Dementias.
Self- and Informant-Reported Memory Complaints: Frequency and Severity in Cognitively Intact Individuals and those with Mild Cognitive Impairment and Neurodegenerative Dementias.
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DOI：
10.3233/jad-180083
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Hampstead BM
中科院分区：
文献类型：
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作者：
Rahman-Filipiak AM;Giordani B;Heidebrink J;Bhaumik A;Hampstead BM
主观记忆主诉（SMC）被纳入轻度认知功能障碍（MCI）和神经退行性痴呆的诊断;然而，认知功能完好的老年人和不同类型痴呆患者中SMC的相对频率知之甚少。同样，在不同的诊断组中，自我报告与报告者报告的SMC之间的一致性也没有进行比较。本研究旨在评估认知完整的成年人或诊断为MCI或神经退行性痴呆的患者中自我报告（目标1）和线人报告（目标2）SMC的频率。还评价了参与者和举报人投诉之间的一致性（目标3）。基线评估数据来自488名被诊断为认知完整、非遗忘型MCI、遗忘型单域MCI、遗忘型多域MCI、可能/很可能阿尔茨海默病、路易体痴呆或额颞叶痴呆的参与者（法师= 70.49岁; Medu = 15.62岁）。参与者和他们的线人完成了记忆评估诊所问卷。控制年龄、教育和抑郁的单向ANCOVA显示，自我报告的SMC的严重程度没有组间差异。相比之下，线人的记忆评级遵循预期的临床模式，具有可比性和最受损的评级给予任何痴呆诊断的参与者，其次是任何MCI诊断的参与者，其次是认知完整的参与者。在任何受损组中，自我报告的SMC评分与举报人报告的SMC评分之间存在不一致的一致性。鉴于线人报告的诊断特异性和内部一致性更高，临床医生在诊断过程中应该比自我报告更重视这些信息。
Subjective memory complaints (SMCs) are incorporated into the diagnosis of mild cognitive impairment (MCI) and neurodegenerative dementias; however, the relative frequency of SMCs in cognitively intact older adults and those with different types of dementia is poorly understood. Similarly, the concordance between self- versus informant-reported SMCs has not been compared across different diagnostic groups. This study aimed to evaluate the frequency of self-reported (Objective 1) and informant-reported (Objective 2) SMCs in cognitively intact adults or those diagnosed with MCI or a neurodegenerative dementia. Agreement between participant and informant complaints was also evaluated (Objective 3). Baseline evaluation data were drawn from 488 participants (Mage = 70.49 years; Medu = 15.62 years) diagnosed as cognitively intact, non-amnestic MCI, amnestic single domain MCI, amnestic multi-domain MCI, possible/probable Alzheimer’s disease, dementia with Lewy bodies, or frontotemporal dementia. Participants and their informants completed the Memory Assessment Clinic Questionnaire. One-way ANCOVAs controlling for age, education, and depression revealed no group differences in severity of self-reported SMCs. In contrast, informant memory ratings followed the expected clinical pattern, with comparable and most impaired ratings given to participants with any dementia diagnosis, followed by those with any MCI diagnosis, followed by cognitively intact participants. There was inconsistent agreement between self- and informant-reported SMC ratings in any of the impaired groups. Given greater diagnostic specificity and internal consistency of informant report, clinicians should weigh this information more heavily than self-report in the diagnostic process.