Level of Vascular Endothelial Growth Factor 165b in Human Aqueous Humor
Level of Vascular Endothelial Growth Factor 165b in Human Aqueous Humor
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DOI：
10.3109/02713683.2013.877935
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发表时间：
2014-08-01
影响因子：
2
通讯作者：
Yamamoto, Shuichi
中科院分区：
文献类型：
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作者：
Baba, Takayuki;Bikbova, Guzel;Yamamoto, Shuichi
目的：血管内皮生长因子165b （VEGF(165)b）是VEGF- a的剪接变体，是一种与促血管生成形式相反的抗血管生成形式。我们比较了77只渗出性年龄相关性黄斑变性（AMD）眼和38只视网膜静脉闭塞（RVO）眼房水中VEGF165b的水平。设计：前瞻性、干预性病例系列。方法：采用酶联免疫吸附法（ELISA）测定VEGF(165)b在AMD、典型、隐匿脉络膜新生血管（CNV）和息肉样脉络膜血管病变（PCV）亚组中的含量。测定AMD和RVO患者VEGF(165)b水平与最大线性尺寸（GLD）、中央中央凹厚度（CFT）、视网膜下液高度（SRF）的关系。结果：57%的AMD患者VEGF(165)b水平高于检测下限（15 pg/ml）(中位数为16.4；
Purpose: Vascular endothelial growth factor 165b (VEGF(165)b) is a splice variant of VEGF-A and is an anti-angiogenic form as opposed to a pro-angiogenic form of VEGF. We compared the level of VEGF165b in the aqueous humor of 77 eyes with exudative age-related macular degeneration (AMD) and 38 eyes with retinal vein occlusion (RVO). Design: A prospective, interventional case series.Methods: The concentration of aqueous VEGF(165)b was measured by enzyme-linked immunosorbent assay (ELISA), and its level in the subgroups of AMD, classic and occult choroidal neovascularization (CNV) and polypoidal choroidal vasculopathy (PCV), was compared. The relationships between the VEGF(165)b level and the greatest linear dimension (GLD), central foveal thickness (CFT), and the height of the subretinal fluid (SRF) were determined for the AMD and RVO cases.Results: The level of VEGF(165)b was higher than the lower limit of detection (15 pg/ml) in 57% of the AMD cases (median, 16.4; range,