Continuous reactive crystallization of pharmaceuticals using impinging jet mixers
Continuous reactive crystallization of pharmaceuticals using impinging jet mixers
复制标题
使用冲击喷射混合器进行药物的连续反应结晶
DOI：
10.1002/aic.15438
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发表时间：
2017-03-01
期刊：
影响因子：
3.7
通讯作者：
Wang, Xue Z.
中科院分区：
文献类型：
--
作者：
Liu, Wen J.;Ma, Cai Y.;Wang, Xue Z.
对于显示快速反应速率、活性药物成分的低溶解度和因此大的过饱和度的药物的反应性结晶，在最近的研究中发现，将撞击射流混合器和分批搅拌罐整合的工艺设计产生高质量的晶体。目前的调查研究，如果反应结晶的短处理时间允许撞击射流混合搅拌槽的设计进行修改，以连续模式操作。新设计结合了用于进料引入和反应的撞击射流混合器与用于晶体生长的连续搅拌釜式反应器（CSTR）和管式反应器。头孢呋辛钠（一种抗生素）的反应结晶研究，首先使用1 L CSTR，然后扩展到50 L CSTR，发现新设计产生的晶体结晶度更高，粒度更窄，产品稳定性更好，比分批结晶器。© 2016美国化学工程师学会AIChE J，63：967-974，2017
For reactive crystallization of pharmaceuticals that show a rapid reaction rate, low solubility of active pharmaceutical ingredient and hence a large supersaturation, it was found in a recent study that a process design which integrates an impinging jet mixer and batch stirred tank produces high quality crystals. The current investigation examines if the short processing time of reactive crystallization permits the impinging jet mixer—stirred tank design to be modified to operate in a continuous mode. The new design combines an impinging jet mixer for feed introduction and reaction with a continuous stirred tank reactor (CSTR) and tubular reactor for crystal growth. A study of reactive crystallization of sodium cefuroxime (an antibiotic), using first a 1L CSTR then scaling to a 50L CSTR, found that the new design produces crystals of higher crystallinity, narrower particle size, and improved product stability, than batch crystallizers. © 2016 American Institute of Chemical Engineers AIChE J, 63: 967–974, 2017