Treadmill running and targeted tibial loading differentially improve bone mass in mice
Treadmill running and targeted tibial loading differentially improve bone mass in mice
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DOI：
10.1016/j.bonr.2019.100195
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发表时间：
2019-06-01
期刊：
影响因子：
2.5
通讯作者：
Wallace, Joseph M.
中科院分区：
文献类型：
--
作者：
Berman, Alycia G.;Hinton, Madicyn J.;Wallace, Joseph M.
跑步机跑步和胫骨负荷是两种常见的模式，用于评估机械刺激对临床前骨骼的作用。跑步机跑步的主要优点是它的生理相关性。然而，所施加的载荷是复杂的和多轴的，所观察到的结果受心血管和肌肉骨骼效应的影响。相比之下，胫骨载荷是对单个骨施加直接单轴载荷，具有更好的控制优势，但生理相关性较低。尽管这两种模式都很重要，而且得到广泛使用，但缺乏直接的比较。在这项研究中，我们在小鼠模型中比较了目标胫骨负荷、跑步机跑步及其组合对松质骨和皮质结构的影响。我们发现，胫骨负荷和跑步机运行差异改善骨量，胫骨负荷导致更厚的骨小梁和增加皮质质量，运动导致更多的骨小梁和无皮质质量为基础的影响。模态的组合导致相加反应。这些数据表明，胫骨负荷和运动可能会改善质量差异。
Treadmill running and tibial loading are two common modalities used to assess the role of mechanical stimulation on the skeleton preclinically. The primary advantage of treadmill running is its physiological relevance. However, the applied load is complex and multiaxial, with observed results influenced by cardiovascular and musculoskeletal effects. In contrast, with tibial loading, a direct uniaxial load is applied to a single bone, providing the advantage of greater control but with less physiological relevance. Despite the importance and widespread use of both modalities, direct comparisons are lacking. In this study, we compared effects of targeted tibial loading, treadmill running, and their combination on cancellous and cortical architecture in a murine model. We show that tibial loading and treadmill running differentially improve bone mass, with tibial loading resulting in thicker trabeculae and increased cortical mass, and exercise resulting in greater number of trabeculae and no cortical mass-based effects. Combination of the modalities resulted in an additive response. These data suggest that tibial loading and exercise may improve mass differentially.