Preparation and structure of drug-carrying biodegradable microspheres designed for transarterial chemoembolization therapy
Preparation and structure of drug-carrying biodegradable microspheres designed for transarterial chemoembolization therapy
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DOI：
10.1080/09205063.2014.982242
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发表时间：
2015-01-22
影响因子：
3.6
通讯作者：
Koole, Leo H.
中科院分区：
文献类型：
--
作者：
Wang, Yujing;Benzina, Abderazak;Koole, Leo H.
采用乳化溶剂挥发法制备了直径为200 ~ 400 μ m的可生物降解的聚（D，L-乳酸）药物洗脱微球。扫描电镜显示顺铂微球表面光滑，而甲苯磺酸索拉非尼微球和顺铂+甲苯磺酸索拉非尼微球表面多孔，后者的凹坑大于前者。值得注意的是，顺铂+甲苯磺酸索拉非尼微球与仅含有一种药物的微球相比具有快速的药物释放速率。体外细胞毒性实验和经典的基质胶内皮细胞试验分别证明了顺铂和甲苯磺酸索拉非尼从微球中释放出来后仍保持生物活性。本工作为经动脉化疗栓塞药物洗脱微球的制备提供了一种有效的方法。
Biodegradable poly(D,L-lactic acid) drug-eluting microspheres containing anti-tumor drugs, cisplatin, and sorafenib tosylate have been prepared by the emulsion solvent evaporation method with diameter between 200 and 400 mu m. Scanning electron microscopy showed that cisplatin microspheres had smooth surfaces, while sorafenib tosylate microspheres and cisplatin+sorafenib tosylate microspheres were porous at the surface and the pits of the latter were larger than those of the former. Notably, cisplatin+sorafenib tosylate microspheres had a fast drug release rate compared with microspheres containing one drug alone. In vitro cytotoxicity experiments and classical matrigel endothelial tube assay certificated the maintaining bioactivity of cisplatin and sorafenib tosylate released from the microspheres, respectively. This work provides a useful approach for the fabrication of drug-eluting beads used in transarterial chemoembolization.