Receptor-mediated phagocytosis of Leishmania: implications for intracellular survival.
Receptor-mediated phagocytosis of Leishmania: implications for intracellular survival.
复制标题
利什曼原虫受体介导的吞噬作用：对细胞内存活的影响。
DOI：
10.1016/j.pt.2012.05.002
复制
发表时间：
2012
影响因子：
9.6
通讯作者：
Wilson,MaryE
中科院分区：
文献类型：
--
作者：
Ueno,Norikiyo;Wilson,MaryE
利什曼原虫的细胞外前鞭毛体阶段。利什曼原鞭毛体连接宿主巨噬细胞受体，触发吞噬作用和随后的内化，这是生存的关键步骤。寄生虫在细胞内转化为无鞭毛体阶段。许多研究记录了不同的受体检测前鞭毛体和无鞭毛体，但每种相互作用的相对重要性是不明确的。最近的研究表明，巨噬细胞受体在吞噬过程中使用的影响寄生虫的细胞内命运。本文综述了近30年来利什曼吞噬细胞症相关受体的研究进展。然后，它继续权衡证据或反对他们的潜在作用，在细胞内寄生虫贩运。
The extracellular promastigote stage ofLeishmaniaspp. is transmitted to mammals by a sand fly vector.Leishmaniapromastigotes ligate host macrophage receptors, triggering phagocytosis and subsequent internalization, a crucial step for survival. Parasites transform intracellularly to the amastigote stage. Many studies document different receptors detecting promastigotes and amastigotes, but the relative importance of each interaction is ill-defined. Recent studies suggest that the macrophage receptors utilized during phagocytosis impact the intracellular fate of the parasite. This review summarizes the receptors implicated inLeishmaniaphagocytosis over the past 30 years. It then proceeds to weigh the evidence for or against their potential roles in intracellular parasite trafficking.