Assembly of a Benzo‐Fused Bridged Ketone Scaffold from 1,5,10‐Enediynes through One‐Pot Ruthenium‐Catalyzed Cyclization/Iodine‐Mediated Oxidative Ring Expansion
Assembly of a Benzo‐Fused Bridged Ketone Scaffold from 1,5,10‐Enediynes through One‐Pot Ruthenium‐Catalyzed Cyclization/Iodine‐Mediated Oxidative Ring Expansion
复制标题
通过一锅钌催化环化/碘介导的氧化扩环从 1,5,10-烯二炔组装苯并稠合桥酮支架
DOI：
10.1002/anie.201700493
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Masatoshi Shibuya
中科院分区：
文献类型：
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作者：
Yoshihiko Yamamoto;Kei‐ichiro Nishimura;Shota Mori;Masatoshi Shibuya
在阳离子Ru催化剂存在下，带有末端苯乙烯基部分的1,6-二炔进行[2+2+2]环化，生成与五元环稠合的脱氢联亚苯基。尽管环加合物对纯化不稳定，但它们的一锅碘介导的扩环成功地提供了前所未有的含有苯并稠合双环[3.2.1]框架的桥联酮产物。
In the presence of a cationic Ru catalyst, 1,6‐diynes bearing a terminal styryl moiety underwent [2+2+2] cyclization to produce dehydrobiphenylenes fused with a five‐membered ring. Although the cycloadducts were unstable toward purification, their one‐pot iodine‐mediated ring expansion successfully afforded unprecedented bridged ketone products containing a benzo‐fused bicyclo[3.2.1] framework.