Epithelial stem cells in adult skin.
Epithelial stem cells in adult skin.
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DOI：
10.1016/b978-0-12-416022-4.00004-4
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发表时间：
2014
影响因子：
--
通讯作者：
Horsley V
中科院分区：
文献类型：
--
作者：
Tadeu AM;Horsley V
皮肤是抵御脱水和外界环境侵害的第一道防线。它在整个成人生活中不断自我更新，主要是由于组织特异性干细胞的活动。在这篇综述中，我们讨论了皮肤内不同干细胞群的基本特征以及它们如何能够促进正常皮肤的稳态。我们还研究了关于成人皮肤上皮内干细胞生态位的细胞内在和外源性成分的最新结果。最后，我们讨论了最近的努力，以了解干细胞活性的异常调节如何促进皮肤相关癌症的发生和进展。
The skin is the first line of defense against dehydration and external environmental aggressions. It constantly renews itself throughout adult life mainly due to the activity of tissue-specific stem cells. In this review, we discuss fundamental characteristics of different stem cell populations within the skin and how they are able to contribute to normal skin homeostasis. We also examine the most recent results regarding the cell-intrinsic and -extrinsic components of the stem cell niche within the adult skin epithelium. Finally, we address the recent efforts to understand how abnormal regulation of stem cell activity contributes to the initiation and progression of skin-associated cancers.