Dehydrative C-H Alkylation and Alkenylation of Phenols with Alcohols: Expedient Synthesis for Substituted Phenols and Benzofurans
Dehydrative C-H Alkylation and Alkenylation of Phenols with Alcohols: Expedient Synthesis for Substituted Phenols and Benzofurans
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DOI：
10.1021/ja302710v
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发表时间：
2012-05-02
影响因子：
15
通讯作者：
Yi, Chae S.
中科院分区：
文献类型：
--
作者：
Lee, Dong-Hwan;Kwon, Ki-Hyeok;Yi, Chae S.
明确的阳离子 Ru-H 络合物催化苯酚与醇的脱水 C-H 烷基化反应，形成邻位取代的苯酚产物。苯并呋喃衍生物是通过酚与1,2-二醇的脱水C-H烯基化和成环反应有效合成的。催化 C-H 偶联方法采用廉价的酚和醇，具有广泛的底物范围，耐受羰基和胺官能团，并释放水作为唯一的副产物。
A well-defined cationic Ru-H complex catalyzes the dehydrative C-H alkylation reaction of phenols with alcohols to form ortho-substituted phenol products. Benzofuran derivatives are efficiently synthesized from the dehydrative C-H alkenylation and annulation reaction of phenols with 1,2-diols. The catalytic C-H coupling method employs cheaply available phenols and alcohols, exhibits a broad substrate scope, tolerates carbonyl and amine functional groups, and liberates water as the only byproduct.