Computational comparison of two draft sequences of the human genome
Computational comparison of two draft sequences of the human genome
复制标题
DOI：
10.1038/35057055
复制
发表时间：
2001-02-15
期刊：
影响因子：
64.8
通讯作者：
Shendure, J
中科院分区：
文献类型：
--
作者：
Aach, J;Bulyk, ML;Shendure, J
我们正处于令人羡慕的位置，拥有两个不同的人类基因组序列草图。虽然差距，错误，冗余和不完整的注释意味着每个单独的福尔斯达不到理想，这些问题中的许多可以通过比较来评估。在此，我们对这些草案进行了一些比较分析。我们研究了序列的一些特征，包括序列缺口、连续性、两个序列之间的一致性和DNA结合蛋白基序的模式。
We are in the enviable position of having two distinct drafts of the human genome sequence. Although gaps, errors, redundancy and incomplete annotation mean that individually each falls short of the ideal, many of these problems can be assessed by comparison. Here we present some comparative analyses of these drafts. We look at a number of features of the sequences, including sequence gaps, continuity, consistency between the two sequences and patterns of DNA-binding protein motifs.