EFFECTS OF CHEMICAL SYMPATHECTOMY ON LIPOPROTEIN-LIPASE ACTIVITIES IN PERIPHERAL-TISSUES OF RATS FED HIGH-FAT DIETS CONSISTING OF DIFFERENT FATS
EFFECTS OF CHEMICAL SYMPATHECTOMY ON LIPOPROTEIN-LIPASE ACTIVITIES IN PERIPHERAL-TISSUES OF RATS FED HIGH-FAT DIETS CONSISTING OF DIFFERENT FATS
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DOI：
10.3177/jnsv.41.377
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发表时间：
1995-06-01
影响因子：
1.6
通讯作者：
SUZUKI, M
中科院分区：
文献类型：
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作者：
MATSUO, T;SUMIDA, H;SUZUKI, M
我们之前曾报道，与红花油饮食相比，牛脂饮食可降低肩胛间棕色脂肪组织、心脏和比目鱼肌中的脂蛋白脂肪酶活性。我们还表明，在牛脂饮食组中，这些外周组织中的交感神经活动（去甲肾上腺素周转率和β-肾上腺素能受体结合）较低。为了证实膳食脂肪对这些与交感神经活动相关的组织中脂蛋白脂肪酶活性的影响，通过用 6-羟基多巴胺治疗对大鼠进行化学交感神经切除。交感神经切除大鼠和对照大鼠用牛脂饮食或红花油饮食喂养8周。交感神经切除术消除了两个饮食组之间肩胛骨间棕色脂肪组织、心脏和比目鱼肌中脂蛋白脂肪酶活性的差异。交感神经切除术增加了体脂百分比，导致牛脂饮食组和红花油饮食组之间没有差异。这些结果表明，牛脂饮食的摄入通过减少交感神经活动来降低脂蛋白脂肪酶活性。
We have previously reported that the feeding of a beef tallow diet gives lower lipoprotein lipase activities in the interscapuler brown adipose tissue, heart and soleus muscle compared with feeding of a safflower oil diet. We have also suggested that sympathetic activities (norepinephrine turnover rates and beta-adrenergic receptor bindings) in these peripheral tissues were lower in the beef tallow diet group. To confirm the effects of dietary fats on the lipoprotein lipase activities in these tissues related to sympathetic activities, rats were chemically sympathectomized by treatment with 6-hydroxydopamine. The sympathectomized rats and control rats were meal-fed with a beef tallow diet or a safflower oil diet for 8 weeks. Sympathectomy abolished the differences in lipoprotein lipase activities in the interscapuler brown adipose tissue, heart and soleus muscle between two dietary groups. The percentage of body fat was increased by sympathectomy, resulting in no difference between the beef tallow diet group and the safflower oil diet group. These results suggest that intake of the beef tallow diet decreased lipoprotein lipase activities by reducing the sympathetic activities.