Anti-inflammatory and antinociceptive effects of active ingredients in the essential oils from Gynura procumbens, a traditional medicine and a new and popular food material
Anti-inflammatory and antinociceptive effects of active ingredients in the essential oils from Gynura procumbens, a traditional medicine and a new and popular food material
复制标题
传统药物和新型流行食品材料白芨芨草精油中活性成分的抗炎和抗伤害作用
DOI：
10.1016/j.jep.2019.111916
复制
发表时间：
2019-07-15
影响因子：
5.4
通讯作者：
Tang, He-Bin
中科院分区：
文献类型：
--
作者：
Huang, Xia-Ling;Li, Xiao-Jun;Tang, He-Bin
民族药理相关性：三七精油在中国南方外用治疗创伤。材料与方法：采用气相色谱-质谱仪(GC-MS)对三七精油(GPEO)中的有效成分进行鉴定，探讨其体内外抗炎、抗伤害作用的机制。结果：与溶剂对照组相比，GPEO及其活性成分(α-品烯、3-卡宾烯和柠檬烯)治疗小鼠的肿胀和疼痛明显减轻。GPEO或其三种活性成分对COX-2过表达和内毒素诱导的Raw264.7巨噬细胞迁移有明显的药理作用。三种成分均可抑制伤害性刺激诱导的炎性细胞浸润和COX-2的过度表达，这可能与GPEO的抗炎作用有关。结论：GPEO与南方人中国的传统用法一致，有望成为一种治疗慢性疼痛的有效外用药物。
Ethnopharmacological relevance: Gynura procumbens is applied topically for the treatment of traumatic injuries in South China.Materials and methods: This study was conducted to identify the active ingredients in the essential oils from Gynura procumbens (GPEO) by Gas Chromatography-Mass Spectrometer (GC-MS) and to elucidate the mechanisms underlying the anti-inflammatory and antinociceptive effects in vivo and in vitro.Results: A reduction in dswelling and pain were observed in mice treated with GPEO or its active ingredients (alpha-pinene, 3-carene, and limonene) compared with mice treated with a solvent control. GPEO or its three active ingredients had potent pharmacological effects on COX-2 overexpression and LPS-induced migration of Raw264.7 macrophages. All three ingredients inhibited nociceptive stimulus-induced inflammatory infiltrates and COX-2 overexpression, which could be responsible for the anti-inflammatory effect of GPEO. However, only 3-carene produced an antinociceptive effect.Conclusion: Consistent with the traditional usage in Southern China, GPEO may serve as a promising potent external therapeutic agent for the treatment of chronic pain.