3D Printing of a Biocompatible Double Network Elastomer with Digital Control of Mechanical Properties
3D Printing of a Biocompatible Double Network Elastomer with Digital Control of Mechanical Properties
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DOI：
10.1002/adfm.201910391
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发表时间：
2020-02
影响因子：
19
通讯作者：
Pengrui Wang;D. Berry;Zhaoqiang Song;Wisarut Kiratitanaporn;Jacob Schimelman;A. Moran;F. He;B. Xi;S. Cai;Shaochen Chen
中科院分区：
文献类型：
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作者：
Pengrui Wang;D. Berry;Zhaoqiang Song;Wisarut Kiratitanaporn;Jacob Schimelman;A. Moran;F. He;B. Xi;S. Cai;Shaochen Chen
大多数3D打印的生物可降解材料都很脆，这限制了它们在顺应性组织中的应用。聚癸二酸甘油-丙烯酸酯(PGSA)是一种合成的生物相容弹性体，与光基3D打印兼容。本文采用基于数字光处理(DLP)的3D打印技术来构建复杂的PGSA网络结构。受自然启发的双网络结构由具有不同机械性能的相互连接的段组成，只需一次打印即可从相同材料中打印出来。到目前为止，这种能力还没有通过任何其他制造技术得到证明。通过细胞存活率分析，证实了PGSA的生物相容性。此外，还利用有限元分析(FEA)模型对单轴拉伸下结构的破坏进行了预测。有限元分析证实，由于使用软段作为牺牲元件，在断裂前DN结构吸收的能量增加了100%，而硬段保持了结构的完整性。利用有限元信息设计，打印出了一种新的DN结构，拉伸试验结果与模拟结果相吻合。这篇文章展示了如何通过基于DLP的3D打印轻松快速地构建几何优化的材料设计，其中可以使用相同的弹性生物材料同时形成不同硬度的明确图案，并且可以针对不同的生物医学应用专门优化整体机械性能。
The majority of 3D‐printed biodegradable biomaterials are brittle, limiting their application to compliant tissues. Poly(glycerol sebacate) acrylate (PGSA) is a synthetic biocompatible elastomer and compatible with light‐based 3D printing. In this article, digital‐light‐processing (DLP)‐based 3D printing is employed to create a complex PGSA network structure. Nature‐inspired double network (DN) structures consisting of interconnected segments with different mechanical properties are printed from the same material in a single shot. Such capability has not been demonstrated by any other fabrication techniques so far. The biocompatibility of PGSA is confirmed via cell‐viability analysis. Furthermore, a finite‐element analysis (FEA) model is used to predict the failure of the DN structure under uniaxial tension. FEA confirms that the DN structure absorbs 100% more energy before rupture by using the soft segments as sacrificial elements while the hard segments retain structural integrity. Using the FEA‐informed design, a new DN structure is printed and tensile test results agree with the simulation. This article demonstrates how geometrically‐optimized material design can be easily and rapidly constructed by DLP‐based 3D printing, where well‐defined patterns of different stiffnesses can be simultaneously formed using the same elastic biomaterial, and overall mechanical properties can be specifically optimized for different biomedical applications.