Matrine inhibits the progression of prostate cancer by promoting expression of GADD45B
Matrine inhibits the progression of prostate cancer by promoting expression of GADD45B
复制标题
苦参碱通过促进 GADD45B 的表达抑制前列腺癌的进展
DOI：
10.1002/pros.23469
复制
发表时间：
2018-04-01
期刊：
影响因子：
2.8
通讯作者：
Li, Qi
中科院分区：
文献类型：
--
作者：
Huang, Hai;Wang, Qiong;Li, Qi
Matrine is a naturally occurring alkaloid extracted from the Chinese herb Sophora flavescens. It has been demonstrated to exhibit antiproliferative properties, promote apoptosis, and inhibit cell invasion in a number of cancer cell lines by modulating the NF‐κB pathway to downregulate the expression of MMP2 and MM9. It has also been shown to improve the efficacy of chemotherapy when it is combined with other chemotherapy drugs. However, the therapeutic potential of matrine for prostate cancer needs to be further studied.
