Cerebral blood flow in glaucoma patients.
Cerebral blood flow in glaucoma patients.
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DOI：
10.1097/ijg.0b013e3182934b6b
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发表时间：
2013-06
影响因子：
2
通讯作者：
Wirostko B
中科院分区：
文献类型：
--
作者：
Harris A;Siesky B;Wirostko B
青光眼损伤被描述为沿视觉通路缓慢进展的神经元退行性过程。在青光眼中发现脑和眼血流量减少以及血管自身调节受损，并与视野丧失有关。在低压型青光眼患者中，通过磁共振成像可以发现弥漫性脑缺血改变。鉴于这些发现，似乎对一些患者来说，青光眼损伤可能是更广泛的血管异常累及大脑的眼部表现，而不是仅仅孤立于眼睛及其直接血管系统的单独过程。
Glaucomatous damage has been described as a slowly progressive neuronal degenerative process along the visual pathway. Decreased cerebral and ocular blood flow as well as impaired vascular autoregulation has been identified in glaucoma and have been shown to correlate with visual field loss. In low-tension glaucoma patients, diffuse cerebral ischemic changes have been detected through magnetic resonance imaging. Given these findings, it seems that for some patients, glaucomatous damage may be the ocular manifestation of a more widespread vascular abnormality involving the brain rather than a separate process isolated only to the eye and its immediate vasculature.