Glycosylation enhances the aqueous sensitivity and lowers the cytotoxicity of a naphthalimide zinc ion fluorescence probe
Glycosylation enhances the aqueous sensitivity and lowers the cytotoxicity of a naphthalimide zinc ion fluorescence probe
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DOI：
10.1039/c5cc04357c
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发表时间：
2015-01-01
影响因子：
4.9
通讯作者：
Li, Jia
中科院分区：
文献类型：
--
作者：
Dong, Lei;Zang, Yi;Li, Jia
通过这项研究，我们证明了使用点击化学的萘二甲酰亚胺锌离子探针的糖基化导致对特定细胞的水敏感性、工作pH范围和靶向能力的改善，以及显著降低的细胞毒性。
With this research we demonstrate that glycosylation of a naphthalimide zinc ion probe, using click chemistry, leads to an improvement of the aqueous sensitivity, working pH range and targeting ability for specific cells, together with significantly reduced cytotoxicity.