Plasma concentrations of brain natriuretic peptide in patients with acute ischemic stroke
Plasma concentrations of brain natriuretic peptide in patients with acute ischemic stroke
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DOI：
10.1159/000083249
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发表时间：
2005-01-01
影响因子：
2.9
通讯作者：
Ohno, K
中科院分区：
文献类型：
--
作者：
Nakagawa, K;Yamaguchi, T;Ohno, K
背景：已知缺血性卒中后会出现急性血压升高和心脏异常。脑钠肽（BNP），这是响应于这种心血管变化产生的，预计将发挥血流动力学的作用。我们测定了脑梗死（CI）患者的血浆BNP浓度，以确定BNP在急性缺血性卒中中的意义。研究方法：该研究招募了88名CI患者、59名原发性高血压患者、44名自发性脑出血患者、22名无症状房颤（Af）患者以及20名年龄和性别匹配的健康志愿者。CI患者分为2个亚组，有Af（27例）或无Af（61例）。对58例CI患者重复测定BNP水平。BNP水平在按梗死面积分类的缺血亚组之间进行比较。分析BNP水平与血流动力学参数的相关性。结果：脑梗死患者BNP水平明显升高，但在亚急性期下降。无Af的CI患者BNP水平与入院时平均动脉压（MAP）及第1天MAP下降程度相关，而有Af的CI患者BNP水平与入院时MAP呈负相关。心源性房颤患者的随访血钠水平与入院时BNP水平呈负相关。结论：本研究提示BNP在急性缺血患者中的血流动力学意义。版权所有（C）2005 S. Karger AG，巴塞尔。
Background: Acute blood pressure (BP) elevation and cardiac abnormalities are known to follow ischemic stroke. Brain natriuretic peptide (BNP), which is produced in response to such cardiovascular alterations, is expected to play a hemodynamic role. We measured plasma BNP concentrations in patients with cerebral infarction (Cl) to determine the implications of BNP in acute ischemic stroke. Methods: Eighty-eight patients with Cl, 59 with essential hypertension, 44 with spontaneous intracerebral hemorrhage, 22 with asymptomatic atrial fibrillation (Af), and 20 age- and sex-matched healthy volunteers were recruited in the study. Cl patients were divided into 2 subgroups either having Af (27 patients) or not (61 patients). BNP levels were repeatedly measured in 58 patients with Cl. BNP levels were compared between ischemic subgroups categorized by size of infarction. Correlation was investigated between BNP levels and hemodynamic parameters. Results: BNP levels in Cl patients were significantly higher, but they decreased in the subacute period. BNP levels in Cl patients without Af were correlated with mean arterial blood pressure (MAP) on admission or the degree of reduction in MAP at day 1, while in Cl patients with Af BNP levels showed negative correlation with MAP on admission. Follow-up serum sodium levels in Cl patients with Af were negatively correlated with BNP levels on admission. Conclusions: This study suggests the hemodynamic implications of BNP in acute ischemic patients. Copyright (C) 2005 S. Karger AG, Basel.