Maternal screening for hypothyroidism and thyroiditis using filter paper specimens.
Maternal screening for hypothyroidism and thyroiditis using filter paper specimens.
复制标题
使用滤纸标本进行母亲甲状腺功能减退症和甲状腺炎筛查。
DOI：
10.1089/jwh.2013.4393
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Naylor,EW
中科院分区：
文献类型：
--
作者：
FoleyJr,TP;Henry,JJ;Hofman,LF;Thomas,RD;Sanfilippo,JS;Naylor,EW
Background and Objective:Hypothyroidism and autoimmune thyroiditis are more prevalent than previously considered in women during pregnancy and the postpartum, and are associated with adverse effects on the mother and her fetus. We determined the efficacy and accuracy of screening women for primary hypothyroidism and autoimmune thyroiditis by testing TSH and two thyroid antibodies (TAb): thyroperoxidase antibodies (TPOAb) and thyroglobulin antibodies (TgAb), in eluates of filter paper specimens collected during early pregnancy and the postpartum.Methods:We enrolled 494 first-trimester pregnant women with no exclusion criteria into a prospective study to detect primary hypothyroidism and autoimmune thyroiditis. Finger stick blood was applied to filter paper, dried in room air, eluted, and promptly tested for TSH and TAb. A total of 178 of the pregnant women (36%) were tested in the early postpartum. Women with abnormal results had confirmatory serum tests.Results:It was found that 91 pregnant women (18.4%) and 43 postpartum women (24.2%) had abnormal TSH values (>4.0 mU/L) and/or positive TAb; 140 pregnant women (28.3%) had TSH values >2.5 mU/L. All subjects with TSH values >4.0 mU/L tested positive for TAb. Eighteen women (3.6%) who tested normal during pregnancy tested abnormal in the postpartum.Conclusions:This study confirms that TSH and TPOAb measured in eluates of blood-spotted filter paper specimens are excellent screening tests to detect primary hypothyroidism and autoimmune thyroiditis in pregnant and postpartum women. Results are very comparable to serum data in this population published in the literature.
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未经治疗的母亲甲状腺功能减退症的后遗症。
影响因子：
5.8
作者：
M. Mitchell;R. Klein
通讯作者：
R. Klein
在妊娠晚期之前纠正严重的母亲甲状腺功能减退症与后代的正常认知结果相关。
影响因子：
6.6
作者：
S. Downing;Leslie Halpern;J. Carswell;Rosalind S. Brown
通讯作者：
Rosalind S. Brown
影响因子：
5.6
作者：
Massoudi, Mehran S.;Meilahn, Elaine N.;Buhari, Alhaji M.
通讯作者：
Buhari, Alhaji M.
DOI：
10.1038/gim.2013.11
发表时间：
2013-05
期刊：
Genetics in medicine : official journal of the American College of Medical Genetics
影响因子：
--
作者：
Evans JP;Berg JS;Olshan AF;Magnuson T;Rimer BK
通讯作者：
Rimer BK
DOI：
10.1097/00006254-200001000-00002
发表时间：
1999-12
期刊：
The New England journal of medicine
影响因子：
--
作者：
J. Haddow;G. Palomaki;Walter C. Allan;Josephine Williams;G. Knight;June Gagnon;Cheryl E. O’heir;M. Mitchell;R. Hermos;S. Waisbren;J. Faix;R. Klein
通讯作者：
J. Haddow;G. Palomaki;Walter C. Allan;Josephine Williams;G. Knight;June Gagnon;Cheryl E. O’heir;M. Mitchell;R. Hermos;S. Waisbren;J. Faix;R. Klein