Lymphatic contractility; a possible intrinsic mechanism of lymphatic vessels for the transport of lymph.
Lymphatic contractility; a possible intrinsic mechanism of lymphatic vessels for the transport of lymph.
复制标题
淋巴收缩性；淋巴管的可能内在机制用于淋巴的运输。
DOI：
10.1084/jem.90.5.497
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发表时间：
1949-11
期刊：
影响因子：
--
通讯作者：
SMITH RO
中科院分区：
文献类型：
--
作者：
SMITH RO
大鼠、小鼠和豚鼠的大多数外周淋巴管具有自发的间歇性收缩。(A)收缩速度与淋巴形成速度成正比，收缩显然是由腔内压力增加引起的。(B)肾上腺素和脑下垂体后叶素引起收缩速度增加或淋巴管痉挛，而诺沃卡因引起运动停止和淋巴管扩张。(C)切断或电刺激股神经和坐骨神经并不改变延髓淋巴管的收缩速度。这种自发的淋巴管收缩能力在兔子和狗身上没有观察到，尽管淋巴管在受到刺激时确实会收缩。肾上腺素、脑下垂体后叶素和诺沃卡因产生的效果与在较小哺乳动物中观察到的效果相同。皮内注射液体、按摩或被动运动导致淋巴管扩张，随后淋巴管迅速恢复到正常管径。淋巴管中瓣膜的频率、淋巴管的扩张性以及它们在压力梯度增加时恢复到正常管径的能力被认为是促成淋巴运输的内在机制的基本要素。
The most peripheral lymphatic vessels of rats, mice, and guinea pigs were found to possess a spontaneous intermittent contractility. (a) The rate of contraction was shown to be directly proportional to the rate of formation of lymph and contractions were apparently initiated by an increase in intraluminal pressure. (b) Epinephrine and pituitrin caused an increased contractile rate, or lymphatic spasm, whereas novocaine caused cessation of movement and lymphatic dilatation. (c) Section or electric stimulation of femoral and sciatic nerves did not alter the contractile rate of popliteal lymphatics. This spontaneous lymphatic contractility was not observed in rabbits and dogs although the lymphatic vessels did contract when irritated. Epinephrine, pituitrin, and novocaine produced the same effects as observed in the smaller mammals. Dilatation of lymphatic vessels produced by intradermal injection of fluid, massage, or passive motion was followed by a rapid return of the vessel to normal caliber. The frequency of valves in lymphatic vessels, the distensibility of the lymphatics, and their ability to return to normal caliber against an increased gradient of pressure are considered to be the essential elements of an intrinsic mechanism contributing to the transport of lymph.