Exploring Changes in Event-Related Potentials After a Feasibility Trial of Inhibitory Training for Bulimia Nervosa and Binge Eating Disorder
Exploring Changes in Event-Related Potentials After a Feasibility Trial of Inhibitory Training for Bulimia Nervosa and Binge Eating Disorder
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DOI：
10.3389/fpsyg.2020.01056
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发表时间：
2020-05-27
影响因子：
3.8
通讯作者：
Blechert, Jens
中科院分区：
文献类型：
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作者：
Chami, Rayane;Treasure, Janet;Blechert, Jens
在一项可行性试验中，我们对神经性暴食症(BN)和暴饮暴食障碍(BED)患者进行了两种形式的联合抑制控制训练和目标规划(即特定于食物的和一般的)进行比较，发现有证据表明对症状有好处，接受特定食物干预的参与者效果更好。本研究的目的是检查行为结果和事件相关电位(事件相关电位；n2和p3波幅)从基线到干预后的变化，这可能表明这些影响的机制。55名参与者在基线和干预后的两次脑电(EEG)会议中完成了Go/no-Go任务。进行/不进行任务包括对低能量密度食物和非食物的“进行”提示，以及对高能量密度食物和非食物的“不进行”提示。排除了信号质量差和/或离群值的数据集，留下48名参与者(N=24个BN；N=24张床)。与一般干预组相比，被分配到特定食物组的参与者在干预后对低能量密度食物的反应时间比非食物组显著减少。从基线到干预后，佣金误差显著增加，无论刺激类型(食物与非食物)和干预组(特定食物与一般)。遗漏错误没有明显变化。P3对“不去”提示的P3波幅在干预后略有下降，但不显著，但与刺激类型(高能量密度食物与非食物)或干预组(食物特有与一般)没有显著的交互作用。从基线到干预后，对“不去”信号的N_2波幅、对“开始”信号的N_2波幅或对“开始”信号的P3波幅没有显著变化。训练效果只能被这些事件相关电位捕捉到。我们讨论了任务范式的局限性，包括它的二选一性质、完成的简易性和效度，并对使用抑制性控制范式探索事件相关电位的未来研究提出了建议。
In a feasibility trial comparing two forms of combined inhibitory control training and goal planning (i.e., food-specific and general) among patients with bulimia nervosa (BN) and binge eating disorder (BED), we found evidence of symptomatic benefit, with stronger effects among participants receiving a food-specific intervention. The aim of the present study was to examine changes in behavioral outcomes and event-related potentials (ERPs; N2 and P3 amplitudes) from baseline to post-intervention that might suggest the mechanisms underpinning these effects. Fifty-five participants completed go/no-go tasks during two electroencephalography (EEG) sessions, at baseline and post-intervention. The go/no-go task included "go" cues to low energy-dense foods and non-foods, and "no-go" cues to high energy-dense foods and non-foods. Datasets with poor signal quality and/or outliers were excluded, leaving 48 participants (N= 24 BN;N= 24 BED) in the analyses. Participants allocated to the food-specific, compared to the general intervention group, showed significantly greater reductions in reaction time to low energy-dense foods, compared to non-foods, by post-intervention. Commission errors significantly increased from baseline to post-intervention, regardless of stimulus type (food vs. non-food) and intervention group (food-specific vs. general). There were no significant changes in omission errors. P3 amplitudes to "no-go" cues marginally, but non-significantly, decreased by post-intervention, but there was no significant interaction with stimulus type (high energy-dense food vs. non-food) or intervention group (food-specific vs. general). There were no significant changes in N2 amplitudes to "no-go" cues, N2 amplitudes to "go" cues, or P3 amplitudes to "go" cues from baseline to post-intervention. Training effects were only marginally captured by these event-related potentials. We discuss limitations to the task paradigm, including its two-choice nature, ease of completion, and validity, and give recommendations for future research exploring ERPs using inhibitory control paradigms.