Structural brain aberrations associated with the dissociative subtype of post-traumatic stress disorder
Structural brain aberrations associated with the dissociative subtype of post-traumatic stress disorder
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DOI：
10.1111/acps.12464
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发表时间：
2016-03-01
影响因子：
6.7
通讯作者：
Lanius, R. A.
中科院分区：
文献类型：
--
作者：
Daniels, J. K.;Frewen, P.;Lanius, R. A.
目的：造成创伤后应激障碍（PTSD）成年受试者灰质结构改变异质性的一个潜在因素是不同程度的解离症状。因此，本研究的目的是测试最近定义的以人格解体和现实感丧失症状为特征的创伤后应激障碍解离亚型是否以体积脑形态的特定差异为特征。方法对59例PTSD患者进行全脑MRI检查。采用基于体素的形态测定法来检测属于（n=15）与不属于（n=44）分离性PTSD亚型患者的组间差异。计算分离（人格解体/现实感丧失）严重程度与灰质体积之间的相关性。结果分离型PTSD患者右侧中央前回和梭状回灰质体积较大，右侧颞下回灰质体积较小。更严重的分离与更大的右额叶中回体积相关。结论首次对分离型PTSD患者的脑灰质体积进行了全脑研究，发现在处理和调节情绪唤醒的区域存在结构畸变。这些可能构成分离性PTSD亚型的特征性生物标志物。
ObjectiveOne factor potentially contributing to the heterogeneity of previous results on structural grey matter alterations in adult participants suffering from post-traumatic stress disorder (PTSD) is the varying levels of dissociative symptomatology. The aim of this study was therefore to test whether the recently defined dissociative subtype of PTSD characterized by symptoms of depersonalization and derealization is characterized by specific differences in volumetric brain morphology.MethodWhole-brain MRI data were acquired for 59 patients with PTSD. Voxel-based morphometry was carried out to test for group differences between patients classified as belonging (n=15) vs. not belonging (n=44) to the dissociative subtype of PTSD. The correlation between dissociation (depersonalization/derealization) severity and grey matter volume was computed.ResultsPatients with PTSD classified as belonging to the dissociative subtype exhibited greater grey matter volume in the right precentral and fusiform gyri as well as less volume in the right inferior temporal gyrus. Greater dissociation severity was associated with greater volume in the right middle frontal gyrus.ConclusionThe results of this first whole-brain investigation of specific grey matter volume in dissociative subtype PTSD indentified structural aberrations in regions subserving the processing and regulation of emotional arousal. These might constitute characteristic biomarkers for the dissociative subtype PTSD.