Potential for antioxidant therapy of cystic fibrosis
Potential for antioxidant therapy of cystic fibrosis
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DOI：
10.1097/01.mcp.0000138997.29276.a1
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发表时间：
2004-11-01
影响因子：
3.3
通讯作者：
Cantin, AM
中科院分区：
文献类型：
--
作者：
Cantin, AM
综述的目的氧化还原状态的变化在气道炎症和粘液流变学中起着重要作用。此外，囊性纤维化（cystic fibrosis transmembrane conductance regulator，CFTR）是囊性纤维化（cystic fibrosis，CF）中的缺陷蛋白，它不仅受氧化还原状态的调节，而且通过谷胱甘肽的跨上皮流动直接调节上皮细胞的氧化还原环境。这篇综述的目的是探讨抗氧化分子在CF的潜在治疗兴趣。最近的研究结果几种抗氧化剂已被证明具有粘液溶解和抗炎特性。一些抗氧化剂，如锌和维生素C也可能有助于增加上皮氯分泌通过CFTR依赖性和独立的途径。其他抗氧化剂在帮助CFTR动员到质膜方面显示出希望。摘要抗氧化剂提供的许多潜在应用水平使这类分子成为CF治疗发展的有前景的领域之一。几种氧化还原调节剂很可能为CF气道疾病的许多方面的治疗提供有用的方法。
Purpose of review Changes in redox state clearly play a role in airway inflammation and mucus theology. Furthermore CFTR (cystic fibrosis transmembrane conductance regulator), the defective protein in cystic fibrosis (CF), not only is regulated by redox state but also directly modulates the epithelial redox environment through transepithelial flux of glutathione. The purpose of this review is to explore the potential therapeutic interest of antioxidant molecules in CF.Recent findings Several antioxidants have been shown to have mucolytic and anti-inflammatory properties. Some antioxiclants such as zinc and vitamin C may also help increase epithelial chloride secretion through CFTR-dependent and independent pathways. Other antioxidants are showing promise in helping CFTR mobilization to plasma membranes.Summary The many levels of potential application offered by antioxidants make this class of molecules one of the promising areas of therapeutic development for CF. Several redox-modulating agents have a high likelihood of providing useful approaches for the treatment of many aspects of CF airway disease.