Chinese herbs nephropathy-associated slimming regimen induces tumours in the forestomach but no interstitial nephropathy in rats
Chinese herbs nephropathy-associated slimming regimen induces tumours in the forestomach but no interstitial nephropathy in rats
复制标题
DOI：
10.1007/s002040050568
复制
发表时间：
1998-11-01
影响因子：
6.1
通讯作者：
Bernard, AM
中科院分区：
文献类型：
--
作者：
Cosyns, JP;Goebbels, RM;Bernard, AM
中草药肾病 (CHN) 是一种快速进展的肾脏间质纤维化，大约 100 名年轻的比利时女性患有中草药肾病，这些女性遵循了含有一些中草药的减肥方案。在 4 名患者中观察到多灶性移行细胞癌 (TCC)。马兜铃酸 (AA) 被怀疑是 CHN 的致病因素，是一种众所周知的致癌物质，但其诱导纤维化的能力从未得到证实。本研究的目的是使用已知会在大鼠中产生肿瘤的 AA 剂量、中毒持续时间和处死延迟来评估后者。我们还测试了这样的假设：减肥方案的其他成分增强了 AA 可能的纤维形成作用。雄性和雌性大鼠每天口服 10 毫克分离 AA/kg，持续 5 天/周，或者口服草药粉末中含有的约 0.15 毫克 AA/kg 每天 5 天/周，并与减肥丸中规定的其他成分一起治疗 3 个月。这些动物分别在3个月和11个月后被处死。处死时，两组动物都出现了预期的肿瘤，但没有出现肾间质纤维化。在人类中观察到的纤维化反应是否是由于物种和/或品系相关的对 AA 反应的差异或其他因素造成的，仍有待确定。有趣的是，尽管添加了芬氟拉明和二乙苯丙酮这两种与瓣膜性心脏病的发展有关的药物，但没有观察到心脏异常。
Chinese herbs nephropathy (CHN), a rapidly progressive interstitial fibrosis of the kidney, has been described in approximately 100 young Belgian women who had followed a slimming regimen containing some Chinese herbs. In 4 patients multifocal transitional cell carcinomas (TCC) were observed. Aristolochic acid (AA), suspected as the causal factor of CHN, is a well known carcinogen but its ability to induce fibrosis has never been demonstrated. The objective of this study was to evaluate the latter using doses of AA, durations of intoxication and delays of sacrifice known to yield tumours in rats. We also tested the hypothesis that a possible fibrogenic role of AA was enhanced by the other components of the slimming regimen. Male and female rats were treated orally with 10 mg isolated AA/kg per day for 5 days/week, or with approximately 0.15 mg AA/kg per day 5 days/week contained in the herbal powder together with the other components prescribed in the slimming pills for 3 months. The animals were killed respectively 3 and 11 months later. At sacrifice, animals in both groups had developed the expected tumours but not fibrosis of the renal interstitium, Whether the fibrotic response observed in man is due to species and/or strain related differences in the response to AA or to other factors, remains to be determined. Interestingly, despite the addition of fenfluramine and diethylpropion, two drugs incriminated in the development of valvular heart disease, no cardiac abnormalities were observed.