Angiographic circulation time and cerebral blood flow during balloon test occlusion of the internal carotid artery
Angiographic circulation time and cerebral blood flow during balloon test occlusion of the internal carotid artery
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DOI：
10.1038/jcbfm.2013.176
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发表时间：
2014-01-01
影响因子：
6.3
通讯作者：
Tominaga, Teiji
中科院分区：
文献类型：
--
作者：
Sato, Kenichi;Shimizu, Hiroaki;Tominaga, Teiji
基于血管造影的球囊试验闭塞(BTO)已经被经验地用于预测对永久性颈动脉闭塞的耐受性。我们验证了脑血管造影时造影剂半球循环时间(HCT)的偏侧性反映BTO术中双侧脑血流量(CBF)不对称的假设。对31例连续行颈内动脉BTO的患者进行了回顾性分析。Hct定义为利用时间-密度曲线计算大脑中动脉和皮质静脉达到峰值的时间间隔。闭塞侧和非闭塞侧的Hct的差值是在BTO期间获得的颈动脉或优势椎动脉造影中计算的。我们评估了Hct的差异与双侧脑血流量不对称之间的相关性，这是通过单光子发射计算机断层扫描定量确定的。闭塞侧Hct为5.3+/-1.5s，局部脑血流量为41.3+/-11.3mL/100g/min，非闭塞侧分别为3.6+/-0.9s和48.4+/-14.9mL/100g/min。Hct的差异与脑血流不对称率密切相关(r(2)=0.89，P<；0.0001)。基于血管造影的脑循环时间测量可以提供有关脑血流动力学的有价值的信息。
Angiography-based balloon test occlusion (BTO) has been empirically used to predict tolerance to permanent carotid artery occlusion. We tested the hypothesis that the laterality of the hemispheric circulation time (HCT) of the contrast medium at cerebral angiography would reflect bilateral asymmetry of the cerebral blood flow (CBF) during BTO. Thirty-one consecutive patients who underwent BTO of the internal carotid artery were retrospectively analyzed. HCT was defined as the interval between the time-to-peak in the middle cerebral artery and the cortical veins calculated using time-density curve. The difference in HCT between the occluded and nonoccluded side was calculated at the carotid or dominant vertebral angiograms obtained during BTO. We estimated the correlation between the difference in HCT and bilateral asymmetry of the CBF, which was quantitatively determined by single-photon emission computed tomography. The HCT was 5.3 +/- 1.5 seconds and regional CBF was 41.3 +/- 11.3 mL/100 g per minute in the occluded side, compared with 3.6 +/- 0.9 seconds and 48.4 +/- 14.9 mL/100 g per minute in the nonoccluded side, respectively. The difference in HCT was strongly correlated with the asymmetry ratio of the CBF (r(2) = 0.89, P < 0.0001). Angiographically based measurement of the cerebral circulation time can provide valuable information concerning cerebral hemodynamics.